ArticleFrontiers in pediatrics2026
Pathogen-associated radiological and serum inflammatory findings in pediatric necrotizing pneumonia: a retrospective analysis.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Necrotizing pneumonia (NP) is a severe but relatively uncommon complication of pediatric community-acquired pneumonia. In recent years, increasing clinical attention has been directed toward pediatric NP. This study aimed to characterize the clinical features, chest CT findings, and serum inflammatory markers of pediatric NP, and to examine pathogen-associated differences in imaging patterns and inflammatory profiles. Materials and methods: We retrospectively reviewed 54 children diagnosed with NP between January 2018 and January 2024.Etiologic agents, chest CT findings, and serum inflammatory markers including white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase, and D-dimer were analyzed. Pathogen-specific comparisons were restricted to single-pathogen cases to reduce classification bias. Mixed infections were analyzed descriptively and were not reassigned to any single-pathogen category. Results: Among 54 patients (mean age 6.29 ± 3.68 years), significant age-related differences in pathogen distribution were observed ( Conclusions: In this cohort, pediatric necrotizing pneumonia was associated with age-related variations in pathogen distribution, inflammatory markers, and chest CT characteristics. Elevated CRP levels were observed in
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