Evidence map›Paper›PMID 42038231›Full record

ArticleFrontiers in pediatrics2026

Associations of cord blood biomarkers with infant colic and excessive crying.

Elisabeth M Simonin, Karen M Switkowski, Sheryl L Rifas-Shiman, Kari C Nadeau, Emily Oken, Jenifer R Lightdale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elisabeth M SimoninDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Karen M SwitkowskiDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Kari C NadeauDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, United States.
Jenifer R LightdaleDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: There are currently no known biomarkers associated with the diagnosis of infant colic, a common early disorder of gut brain interaction (DGBI) that has been found to predict adverse health outcomes, including atopy, migraines and other DGBIs. Infant colic manifests as unsoothable crying and is perceived to be associated with abdominal pain, differentiating it from other crying behaviors. Prior studies have postulated it may involve microbial dysbiosis as well as immunological and neurological dysregulation. The aim of our study was to investigate the associations of cord blood biomarkers at birth with parent reports of colic and excessive crying behaviors at 6 months of age. Methods: We used available data from Project Viva a pre-birth cohort based in the greater Boston, MA area. All infants were born between 1999 and 2002. Results: Among participants with information on infant colic and cord blood biomarkers ( Discussion: This exploratory study examined cord blood biomarkers of inflammation or immune dysregulation to support the underlying mechanism of infant colic, and identified trans fatty acid levels and

Indexed as

biomarkercord blood microbiomeGammaproteobacteriainfant colictrans fatty acids

Identifiers

PMID42038231
PMCPMC13106567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.