Risk factors for pediatric invasive pneumococcal disease complicated by purulent meningitis.

Objective: To analyze the risk factors associated with invasive pneumococcal disease (IPD) complicated by purulent meningitis in children, with the goal of enhancing early diagnosis and treatment, preventing complications, and improving patient outcomes. Methods: The study involved 56 pediatric patients with IPD and admitted to our hospital from January 2016 and December 2024. Patients were stratified into two groups based on the presence or absence of purulent meningitis. Clinical characteristics and laboratory parameters were collected and analyzed using univariate and multivariate methods to identify risk factors. A risk prediction model based on logistic regression was developed, and its performance was assessed via the area under the receiver operating characteristic (ROC) curve. Results: The study cohort comprised 27 males and 29 females, including 13 patients with purulent meningitis and 43 without. Underlying diseases were present in 53.84% (7/13) of the purulent meningitis group compared to 4.65% (2/43) in the non-meningitic group ( Conclusion: Elevated PCT and NLR levels constitute independent risk factors for IPD complicated by purulent meningitis. The combined predictive model based on PCT > 4.215 ng/mL and NLR > 12.94 demonstrates robust clinical utility.