ArticleFrontiers in pediatrics2026
Clinical characteristics of Mycoplasma pneumoniae pneumonia in children with atopic constitution and risk factors for disease severity: a retrospective comparative study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To compare the clinical characteristics and immune-inflammatory markers between Mycoplasma pneumoniae pneumonia children with and without atopic constitution, and to identify independent risk factors for severe MPP within the atopic group. Methods: We retrospectively analyzed the medical records of 377 children diagnosed with MPP at Wuhan Children's Hospital between January 1, 2019, and December 31, 2024, who underwent allergen-specific immunoglobulin E (sIgE) testing for both inhalant and food allergens. The children were divided into two groups based on their atopic constitution: the atopic constitution group ( Results: Among the 377 children with MPP, 282 (74.8%) were identified as having an atopic constitution. Within the atopic constitution group ( Conclusion: Children with an atopic constitution exhibited a significantly higher prevalence of airway hyperreactivity symptoms during Mycoplasma pneumoniae infection compared to those without an atopic background. Clinically, high serum ferritin and IgE levels should be considered important independent risk factors for predicting severe MPP in children with an atopic constitution, which could facilitate early intervention and improve prognosis.
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