ArticleFrontiers in pediatrics2026
The relationship between serum MOG-IgG titer status and titers and the prognosis of pediatric MOGAD: a retrospective cohort study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To explore the clinical value of MOG-IgG serum titer change and duration in predicting the relapse of MOGAD in children. Methods: The clinical data, imaging data and laboratory examination results of 63 children with MOGAD were analyzed, and the relationship between serum MOG-IgG titer, titer status and disease relapse was examined. Results: (1) 55 children were positive for MOG-IgG serum titers. According to the titer status, there were 24 cases in the transient positive group and 31 cases in the continuous positive group. There were 36 cases in the low MOG-IgG titer group (≤1:32) and 19 cases in the high MOG-IgG titer group (>1:32). Eight cases were children with overlap syndrome. (2) Compared with the transient positive group, the probability of relapsing in the persistent positive group may be higher ( Conclusions: The persistent positive state of MOG-IgG is an important marker of recurrence and poor prognosis. Children with high titers of MOG-IgG at onset or those who do not turn negative within 3 months may be considered to extend the immunotherapy period. Careful examination of the serum titer status and titer of MOG-IgG, combined with clinical data, can guide the clinical further analysis of the prognosis of MOGAD.
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