ArticleFrontiers in pediatrics2026
Calibrated abdominal compression to assess fluid responsiveness in extremely and very preterm neonates: a pilot study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Predicting fluid-responsiveness is challenging in preterm neonates. It is however crucial to avoid unnecessary fluid bolus that could lead to fluid overload. In children, stroke volume changes induced by an abdominal compression (ΔSV-AC) can predict fluid responsiveness. This exploratory pilot study aimed to evaluate the feasibility and tolerance of this preload challenge in preterm neonates. Materials and methods: This prospective, single-center pilot study was conducted in a tertiary neonatal intensive care unit. Mechanically-ventilated and sedated preterm neonates under 32 weeks of corrected gestational age who required a 10 mL.kg Results: Eighteen fluid boluses were analyzed. Fluid-responsiveness was observed in 8 (44%) cases. The calibrated abdominal compression and the echocardiographic measurements were feasible in all cases. Although no serious adverse events were attributed to the maneuver, we observed three cases of transient but significant decreases in stroke volume or heart rate, two of which were accompanied by a subjective impression of poor tolerance. All other cases were subjectively rated as well tolerated. In exploratory analysis, after adjustment for repeated measures, the AUROC of ΔSV-AC to predict fluid-responsiveness was 0.76 (95% CI 0.43-1). The best threshold for ΔSV-AC was 17% with a specificity of 0.91 (95% CI 0.60-1), a sensitivity of 0.51 (95% CI 0.17-1), and positive and negative predictive values of 0.85 (95% CI 0.36-1) and 0.68 (95% CI 0.33-1) respectively. Conclusions: This study suggests that calibrated abdominal compression could be feasible in a population of critically ill preterm neonates mostly suffering from PPHN-related shock, although its tolerance is uncertain. Further studies are needed to better tailor this maneuver to preterm neonates and to characterize its diagnostic accuracy, including in more common etiologies of neonatal shock.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.