ArticleGalen medical journal2024
Healing Effects of Luteolin Versus Silver Sulphadiazine on Second-Degree Burn Wounds in Animal Model.
Article in Galen medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBurn wounds are one of the most important injuries with significant mortality and morbidity. Although some treatments like silver sulphadiazine (SSD) ointment were introduced, the more effective as well as lower complications agents are under investigation. Current evidence shows that luteolin, as a flavonoid component of some fruits and vegetables, has potent anti-inflammatory and antioxidative properties. Hence this study aimed to investigate the healing effects of luteolin ointments on second-degree burn wounds in rat models and compared it with SSD. MATERIALS AND
methodsThirty male rats were randomly divided into five equal groups. A 2×2 cm2 circled second-degree wound was induced on the dorsal surface of the rat neck. In the control group, rats received no any treatments while in the vehicle group rats received ointment base, i.e., eucerin. Rats in positive control and experimental groups were treated with SSD and luteolin ointments (i.e., contained 2 and 5 percent of luteolin), respectively. The treatments of rats were performed daily for 17 days and wound closer rate (WCR) was measured. Also, histopathological examinations graded the severity of tissue damages using the determination of collagen formation, re-epithelialization, angiogenesis rate, and polymorphological leukocyte density.
resultsOn the 17th day, WCR in control and vehicle groups was markedly lower than in both treatment and experimental groups (P0.005). Also, WCRs in the L2% and L5% groups were higher than the SSD group. Histopathological studies indicated more significant wound healing effects of L2% and L5% ointments versus SSD and eucerin treatments in terms of tissue-enhanced damage severity in a dose-dependent manner. Also, collagen formation and re-epithelialization were markedly more observed in the rats, which received luteolin ointments than in other groups.
conclusionOur study revealed that based on WCR and histopathological examination findings, luteolin ointments could significantly enhance wound healing more than SSD (as the standard treatment) in the second-degree wounds rat model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.