Evidence map›Paper›PMID 42038128›Full record

ArticleGalen medical journal2024

Therapeutic Potential of Alpha-pinene in Breast Cancer: Targeting miR-21 and PTEN Gene Expression.

Mohammad Yazdi, Mahdi Alaee, Shana Ahadi, Parisa Khanicherag, Elham Ghayem, Ghasem Farhadi Galil Babadi, Fatemeh Ghiasi, Mojgan Azadpour

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Article in Galen medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Regulatory Effects ofFood science & nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad YazdiRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Mahdi AlaeeDepartment ofclinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Shana AhadiSchool of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.
Parisa KhanicheragStudent Research Committee,Tabriz University of Medical Sciences, Tabriz , Iran.
Elham GhayemDepartment of Internal Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ghasem Farhadi Galil BabadiRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Fatemeh GhiasiInstructor of critical care nursing, Department of Anesthesiology, School of Allied Medical Sciences, Ayatollah Taleghani Hospital, Ilam University of Medical Sciences, Ilam, Iran.
Mojgan AzadpourRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlpha-pinene is an organic compound with anticancer properties. This compound has been used as a therapeutic factor in breast cancer (BC). miR-21 causes cancer cell invasion by inhibiting Phosphatase and tensin homolog (PTEN). The present study evaluates the potential effect of Alpha-piene on the expression of PTEN and miR-21 genes in BC cells (MCF-7 cell line). MATERIALS AND

methodsIn this study, the MCF-7 cell line was used. The cells were treated with Alpha- pinene. The viability of cells with different Alpha-pinene concentrations (i.e., 40, 50, 100, 150, and 200 μM) was evaluated with MTT assay. The expression of PTEN and miR-21 genes was evaluated using RT-qPCR.

resultsThe survival rate of cells in all concentrations was higher 24 h after treatment compared to 48 h after the treatment (P0.0001). The expression of miR-21 in cells treated with 100 and 50 μMof Alpha- pinene reduced significantly compared to the control cells(P0.001). PTEN gene expression was exactly the opposite of miR-21. Therefore, its expression increased significantly in cells treated with 100 μM of Alpha- pinene compared to the control cells (P0.0001).

conclusionIn general, the use of Alpha- pinene led to decreased and increased expression of miR-21 and PTEN, respectively. These changes lead to the reduction of invasion and proliferation of BC cells. Therefore, the Alpha- pinene combination can be used as a therapeutic strategy to treat patients.

Indexed as

Alpha-pineneBreast CancermiR-21PTEN

Identifiers

PMID42038128
PMCPMC11999240

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.