Evidence map›Paper›PMID 42038126›Full record

ArticleGalen medical journal2024

Plasma Amino Acid Profiles and Clinical Outcome in Patients with Traumatic Brain Injury: A Study Protocol.

Alireza Gheflati, Mostafa Shahraki Jazinaki, Mahlagha Nikbaf-Shandiz, Pegah Rahbarinejad, Hamid Rezaee, Saeid Eslami, Majid Khadem-Rezaian, Alireza Sedaghat, Mohsen Nematy, Mahdi Shadnoush and 4 more

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Article in Galen medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alireza GheflatiDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mostafa Shahraki JazinakiDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahlagha Nikbaf-ShandizStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Pegah RahbarinejadDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Hamid RezaeeDepartment of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Saeid EslamiDepartment of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid Khadem-RezaianDepartment of Community Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Alireza SedaghatDepartment of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohsen NematyDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahdi ShadnoushDepartment of Clinical Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ali Jafarzadeh EsfehaniMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh KeyfiDepartment of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
Zachary S ClaytonDepartment of Integrative Physiology, University of Colorado, Boulder, CO, USA.
Abdolreza NorouzyDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe most common cause of cognitive and behavioral impairments, disability, and mortality around the world is traumatic brain injury (TBI). The imbalance between cerebral metabolism and inflammation leads to protein breakdown and induces altered concentrations of serum amino acids, which can serve as a diagnostic and prognostic sign in patients with TBI. This study aimed to examine the alterations in plasma amino acid concentrations and their relation to clinical outcomes in patients with TBIs. MATERIALS AND

methodsAt completion, this study will assess 107 patients suffering from TBI aged 18 to 65. Plasma amino acid concentrations, anthropometric indices, and clinical outcome parameters including Acute Physiology and Chronic Health Evaluation (APACHE) II, Sequential Organ Failure Assessment (SOFA), Nutrition Risk in the Critically ill (Nutric) score, Glasgow coma scale (GCS), Intensive Care Unit (ICU) discharge time, mechanical ventilator duration, and mortality rate will be assessed at the beginning of the study, day 7, and day 14.

conclusionThis longitudinal study will provide evidence for further clinical trials and observational studies on amino acid supplementation and TBI. The results of this study could inform future treatment strategies for TBI patients.

Indexed as

Amino AcidClinical ProtocolsMortalityTraumatic Brain Injury

Identifiers

PMID42038126
PMCPMC11827877

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