ArticleLaryngoscope investigative otolaryngology2026
Weight Loss and Chronic Rhinosinusitis in the Obese Population: Associations With Disease Risk and Burden.
Article in Laryngoscope investigative otolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Weight Loss and Chronic Rhinosinusitis in the Obese Population: Associations With Disease Risk and Burden.Laryngoscope investigative otolaryngology · 2026Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Obesity is associated with increased risk and severity of chronic rhinosinusitis (CRS), yet the impact of weight loss (WL) on CRS development and burden is not well defined. This study investigates whether weight reduction influences the likelihood of developing CRS and improves clinical outcomes among obese adults. Methods: Retrospective cohort study using the NIH All of Us database. Obese adults (BMI ≥ 30) with complete demographics and follow-up were included. To assess CRS onset, patients were stratified into sequential WL cohorts and followed for 1 year. To assess CRS outcomes, patients who lost ≥ 5 BMI points were categorized into any WL (AWL), unsustained WL (UWL), or sustained WL (SWL; ≥ 1, 2, 3 years) and compared with no WL (NWL) controls matched on demographics and healthcare visit frequency. Time-to-event analyses used Kaplan-Meier and Cox models to evaluate CRS onset. Among CRS patients, follow-up visits, new nasal symptoms, and medication use were analyzed using odds ratios (ORs). Results: Among 3203 obese patients, a ≥ 5-BMI decrease was associated with reduced CRS risk versus NWL (HR 0.57, 95% CI 0.37-0.87). Of 2714 obese CRS patients, 537 lost weight. Two-year SWL was associated with fewer follow-up CRS visits versus NWL (10.4% vs. 20.1%; OR 0.46, 95% CI 0.24-0.90). Any SWL demonstrated lower odds of nasal symptoms, and 2-year SWL demonstrated reduced antibiotic usage (OR 0.43, 95% CI 0.21-0.88). Conclusion: Sustained WL may reduce both the risk of developing CRS and the burden of ongoing disease, supporting its relevance as a potential adjunctive management strategy. Level of Evidence: Level III.
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Registered trials
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