Evidence map›Paper›PMID 42038090›Full record

ArticleFrontiers in psychiatry2026

My Cosmos: development, clinical protocol, and preliminary usability of a gamified transdiagnostic digital CBT platform.

Sasha Del Vecchio, Tommaso Barlattani, Antonino Carcione, Francesca Pacitti, Marco Recchioni

Abstract read
In one paragraph

Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sasha Del VecchioDepartment of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, L'Aquila, Italy.
Tommaso BarlattaniDepartment of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, L'Aquila, Italy.
Antonino CarcioneDepartment of Human Sciences, Guglielmo Marconi University, Rome, Italy.
Francesca PacittiDepartment of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, L'Aquila, Italy.
Marco RecchioniDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Digital cognitive-behavioural therapy (dCBT) has been shown to be effective for anxiety and depression, yet sustaining engagement remains a key challenge that limits real-world impact. Gamification and extended reality (XR) elements may support motivation and skill transfer, but few interventions integrate these features within a clinician-compatible, clinically grounded framework. My Cosmos is an internet-delivered, mobile-first transdiagnostic dCBT programme that embeds first-wave CBT alongside selected second- and third-wave approaches within a game-inspired structure designed to support adherence and self-regulation. Methods: My Cosmos was developed through evidence mapping, co-design with potential users and mental health professionals, iterative prototyping, and implementation of GDPR-compliant pseudonymised data flows. The programme assigns users to Anxiety, Depression, or Mixed tracks based on baseline PHQ-9, GAD-7, and SF-36 scores. Each track follows a six-module CBT pathway enriched with gamified Rehabilitation Objects and supported by a secure clinician web dashboard to enable blended care. Preliminary usability and acceptance were assessed through participatory workshops with university students (N = 124) and mental health professionals (N = 19), using standardised questionnaires (SUS, MAUQ, UTAUT2) and inductive qualitative analysis of open-ended feedback. Results: Help-seekers described My Cosmos as intuitive, engaging, and emotionally supportive, emphasising its usefulness for self-regulation and structured reflection. Mental health professionals reported more moderate but overall positive evaluations, recognising the platform's value for supporting homework, monitoring progress, and enhancing continuity between sessions, while highlighting the importance of clear onboarding, transparent communication about data protection, and flexible clinical integration. Both groups converged on a blended-care positioning in which the programme complements, rather than replaces, the therapeutic relationship. Conclusions: This paper presents the development, clinical protocol, and early-stage usability evaluation of My Cosmos, a gamified, modular, transdiagnostic dCBT programme implemented within a secure digital environment. Findings inform ongoing optimisation and support progression toward beta/feasibility testing and a planned randomised controlled trial to evaluate clinical effectiveness, engagement, and health-economic outcomes.

Indexed as

blended caredigital cognitive behavioural therapydigital mental healthgamificationtransdiagnostic interventionusability and acceptability

Identifiers

PMID42038090
PMCPMC13106314

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.