Evidence map›Paper›PMID 42038010›Full record

ReviewBiodesign research2026

Advances in luminescence-based tracing technologies: applications and future perspectives.

Siyuan Sun, Tiange Wang, Yingzi Li, Hao Du

Abstract readReview
In one paragraph

Review in Biodesign research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Siyuan SunCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Tiange WangCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Yingzi LiCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Hao DuCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Luminescence-based imaging is a fundamental tool for visualizing dynamic biological processes, primarily through bioluminescence, which generates light via enzyme-substrate reactions, and fluorescence, which requires external excitation. The recent emergence of self-sustaining systems like the fungal bioluminescence pathway (FBP) necessitates a renewed comparative analysis of these tracing technologies. Conventional tools for biological tracing, luciferases and fluorescent proteins, are limited by their dependence on external substrates or light excitation. This review systematically contrasts these methods with the self-sustaining FBP, an intrinsic metabolic circuit that enables substrate-free, autonomous bioluminescence. We conclude that integrating FBP with AI-driven protein design is the pivotal next step toward non-invasive, real-time monitoring in complex organisms, positioning FBP as a paradigm-shifting tool for future tracing technologies.

Indexed as

Artificial intelligenceFungal bioluminescent pathwayGreen fluorescent proteinLuciferaseTracing technologies

Identifiers

PMID42038010
PMCPMC13109339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.