ReviewCureus2026
The Role of Lasers in Enhancing Growth Factor-Mediated Regenerative Endodontic Procedures: A Systematic Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regenerative endodontics focuses on biologically restoring the pulp-dentin complex in immature permanent teeth affected by necrosis. Endogenous growth factors (GFs) such as vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), and bone morphogenetic proteins (BMPs) play a key role in regulating cellular processes involved in tissue repair and regeneration. Recently, laser technologies have emerged as promising adjuncts for enhancing regenerative outcomes by stimulating cellular activity and GF release. This systematic review aimed to evaluate the influence of laser applications on GF expression and related regenerative outcomes in human dental tissues. The review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and included human-based in vitro, ex vivo, and in vivo studies that investigated the effects of laser energy on GF activity during regenerative endodontic procedures (REPs). Risk of bias was assessed using the Quality Assessment Tool for In Vitro Studies (QUIN). 15 studies fulfilled the inclusion criteria. Diode lasers with wavelengths ranging from 450-980 nm were the most commonly used, while two studies evaluated Er:YAG lasers. Most studies demonstrated increased expression of GFs such as VEGF, TGF-β1, PDGF, and BMPs, along with enhanced markers of odontogenic, osteogenic, and neurogenic differentiation. However, heterogeneity in laser parameters and experimental designs limited direct comparison across studies. Within the limitations of predominantly preclinical evidence, laser therapy appears to enhance biological signaling pathways associated with pulp-dentin regeneration. Nevertheless, well-designed clinical trials are required to establish standardized protocols and confirm long-term clinical outcomes in regenerative endodontics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.