ArticleCureus2026
Managing Rectal Adenocarcinoma in a Radiation-Exposed Patient: A Case Report Utilizing the PROSPECT Trial Protocol.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report describes a 76-year-old woman with newly diagnosed rectal adenocarcinoma and a complex oncologic history, including stage IV cervical cancer previously treated with pelvic chemoradiation, which resulted in significant long-term complications. Given her prior extensive radiation exposure, standard neoadjuvant chemoradiation posed substantial toxicity risks. A chemotherapy-first approach, informed by the PROSPECT trial protocol, was therefore implemented. The patient received neoadjuvant FOLFOX chemotherapy followed by surgical resection, achieving tumor regression and favorable pathological outcomes without additional pelvic radiation. This case illustrates the potential role of a PROSPECT-informed, radiation-sparing strategy in carefully selected patients with locally advanced rectal cancer and prior pelvic irradiation, highlighting the importance of individualized, multidisciplinary treatment planning in complex oncologic scenarios.
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Registered trials
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