Evidence map›Paper›PMID 42037867›Full record

ArticleCureus2026

Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios as Predictors of Complicated Acute Appendicitis: A Retrospective Cohort Study.

Rafael Goncalves Nicastro, Bruno Amantini Messias, Yohran Cacciatori da Silva, Rodrigo Brasileiro de Souza, Julia Vitoria Nunes de Aquino, Priscila Benitz Rios de Oliveira, Erica Rossi Mocchetti, Cirenio de Almeida Barbosa, Marcelo Augusto Fontenelle Ribeiro Junior, Jaques Waisberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rafael Goncalves NicastroDepartment of Surgery, State Public Servant Hospital (IAMSPE), São Paulo, BRA.
Bruno Amantini MessiasDepartment of Surgery, General Hospital of Carapicuiba, Carapicuiba, BRA.
Yohran Cacciatori da SilvaMedical School, São Camilo University Center, São Paulo, BRA.
Rodrigo Brasileiro de SouzaMedical School, São Camilo University Center, São Paulo, BRA.
Julia Vitoria Nunes de AquinoMedical School, São Camilo University Center, São Paulo, BRA.
Priscila Benitz Rios de OliveiraMedical School, 9 de Julho University, São Paulo, BRA.
Erica Rossi MocchettiMedical School, São Camilo University Center, São Paulo, BRA.
Cirenio de Almeida BarbosaDepartment of Surgery, Ouro Preto University, Ouro Preto, BRA.
Marcelo Augusto Fontenelle Ribeiro JuniorR Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, USA.
Jaques WaisbergDepartment of Surgery, ABC Medical School, Santo André, BRA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute appendicitis (AA) is a frequent cause of acute abdominal pain in emergency departments. We aimed to evaluate the association and discriminatory performance of the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) for identifying complicated acute appendicitis. METHODOLOGY: In this retrospective study, we analyzed 483 patients treated at the General Hospital of Carapicuiba from January 2018 to June 2024. Normality was assessed using the Shapiro-Wilk test, and bivariate comparisons were performed using the Mann-Whitney test. Multivariate logistic regression was used to investigate the association of complicated AA with NLR, PLR, age, and sex. A receiver operating characteristic (ROC) curve was constructed to determine sensitivity, specificity, and the area under the curve (AUC). Statistical significance was set at

resultsOf 483 patients, 273 (56.5%) had complicated appendicitis. Median NLR and PLR were higher in complicated versus uncomplicated cases (

conclusionsNLR and PLR were associated with complicated appendicitis in unadjusted analyses. After adjustment for age and sex, only PLR remained independently associated. Given their low cost and wide availability, these ratios may complement clinical assessment to support risk stratification and timely management, particularly in resource-limited settings.

Indexed as

acute appendicitisbiomarkersneutrophil-lymphocyte ratioplatelet-lymphocyte ratiorisk stratificationseverity

Identifiers

PMID42037867
PMCPMC13104693

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.