ReviewCureus2026
Hyperbaric Oxygen Therapy in Surgical Wound Healing and Tissue Salvage: A Structured Narrative Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Chronic Radiation-Induced Wounds: Pathogenesis, Current Therapeutic Strategies, and Emerging Regenerative Approaches.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical wound complications remain a major source of postoperative morbidity, particularly in the setting of tissue hypoxia, ischemia, and impaired perfusion. Hyperbaric oxygen therapy (HBOT) has emerged as an adjunctive modality aimed at enhancing tissue oxygen delivery and optimizing wound healing dynamics across diverse surgical contexts. A structured narrative review of the literature was conducted using PubMed/MEDLINE to identify clinical studies, systematic reviews, and translational investigations evaluating the role of HBOT in surgical wound healing and tissue salvage. The search included articles published from January 2000 to February 2026. Evidence was synthesized descriptively, focusing on mechanistic pathways, clinical indications, reconstructive applications, and reported outcomes. HBOT exerts therapeutic effects through multiple physiological mechanisms, including enhanced plasma-dissolved oxygen delivery, angiogenesis stimulation, fibroblast proliferation, collagen synthesis, and immunomodulation. Clinical evidence supports its use in chronic ischemic wounds, such as diabetic foot ulcers, venous leg ulcers, burn injuries, and radiation-induced tissue damage, demonstrating improved wound closure rates and reduced infection risk. In reconstructive surgery, HBOT has shown benefit in compromised grafts, ischemic flaps, traumatic soft-tissue injuries, and breast reconstruction salvage. Reported outcomes include enhanced tissue viability, reduced necrosis progression, improved graft integration, and decreased amputation rates in high-risk populations. HBOT represents a biologically active adjunct capable of enhancing surgical wound healing and tissue salvage through multifactorial regenerative mechanisms. As its applications continue to expand into reconstructive and aesthetic surgical domains, HBOT is positioned to play an increasingly integrative role within multidisciplinary perioperative care and complex wound management strategies.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.