ArticleCureus2026
Recalcitrant Perioral Dermatitis Successfully Controlled With Low-Dose Isotretinoin: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the case of a 45-year-old woman with recalcitrant perioral dermatitis resistant to multiple topical and systemic therapies who achieved complete remission following treatment with oral isotretinoin. The patient presented with persistent periorificial papules despite ivermectin-based topical regimens, calcineurin inhibitors, compounded anti-inflammatory formulations, and repeated courses of doxycycline. Sustained disease control was achieved with low-dose isotretinoin maintenance therapy. This case highlights the therapeutic challenges associated with refractory perioral dermatitis and supports the potential role of isotretinoin as an antibiotic-sparing strategy in selected patients.
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Registered trials
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