ArticleCureus2026
A Clinical and Pathological Analysis of Seven Cases of Salivary Gland Ductal Carcinoma.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective Salivary duct carcinoma (SDC) is a rare but highly aggressive malignancy. Due to its low incidence, most published data are derived from small retrospective series or case reports, and the optimal diagnostic work-up, prognostic stratification, and treatment algorithms remain poorly defined. This study aimed to investigate the clinical characteristics, pathological features, and treatment strategies for SDC by reviewing the relevant literature. Methods A retrospective analysis was conducted on the clinical and pathological data, histological morphology, immunophenotypic characteristics, and treatment outcomes of seven patients with SDC. Additionally, the relevant literature regarding SDC was also reviewed. Results Among the patients, six were male, and one was female, with a mean age at onset of 58 ± 13.84 years. Most cases occurred in the parotid gland (4/7), followed by the submandibular gland (2/7) and the upper lip mucosa (1/7). The tumors exhibited histological features similar to those of breast cancer, with atypical cells arranged in cribriform, nest-like, and linear patterns. The cells had large nuclei with prominent nucleoli, abundant eosinophilic cytoplasm, and an infiltrative growth pattern. Immunohistochemistry showed positive staining for CKpan, CK8/18, CEA, EMA, AR, 34βE12, and GATA3. The Ki67 proliferation index was high, whereas P63, P40, calponin, S100, SMA, and ER were negative. Some cases showed weak positivity for PR and strong positivity for HER2. Conclusions SDC is a rare but highly aggressive malignant salivary gland tumor characterized by a strong propensity for local invasion and an unfavorable prognosis. It carries a high risk of early local recurrence and both regional and distant metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.