Evidence map›Paper›PMID 42037761›Full record

ArticleBio-protocol2026

Quantifying Epigenetic Changes Induced by Chemical Exposure Using the epi-TK Assay.

Shiro Kuroki, Haruto Yamada, Mizuki Odagiri, Kei-Ichi Sugiyama, Manabu Yasui, Akira Sassa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bio-protocol, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shiro KurokiDepartment of Biology, Graduate School of Science, Chiba University, Chiba, Japan.
Haruto YamadaDepartment of Biology, Graduate School of Science, Chiba University, Chiba, Japan.
Mizuki OdagiriDepartment of Biology, Graduate School of Science, Chiba University, Chiba, Japan.
Kei-Ichi SugiyamaDivision of Genome Safety Science, National Institute of Health Sciences, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, Japan.
Manabu YasuiDivision of Genome Safety Science, National Institute of Health Sciences, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, Japan.
Akira SassaDepartment of Biology, Graduate School of Science, Chiba University, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic modifications play essential roles in regulating gene expression and maintaining cellular identity. Accumulating evidence suggests that chemical agents can contribute to carcinogenesis through epigenetic alterations, such as changes in DNA methylation and histone modifications, even in the absence of direct DNA damage. Here, we have developed a simple, cost-effective, and quantitative reporter assay, termed the epi-TK assay, to evaluate chemically induced epigenetic alterations. The assay is built upon the thymidine kinase (

Indexed as

DNMT inhibitorEpi-genotoxicityReporter assayTK6TK geneToxicology

Identifiers

PMID42037761
PMCPMC13103964

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.