ArticleEJHaem2026
Clonally Distinct FLT3-TKD Mutations in Host and Donor-Derived AML After Double Cord Blood Transplant: A Case Report.
Article in EJHaem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Donor-derived leukemia (DDL) is a rare complication of hematopoietic cell transplantation with poorly understood mechanisms. We report a case of DDL arising 1 year after double cord blood transplant for AML. The secondary leukemia demonstrated a distinct immunophenotype, donor origin, and novel mutations (FLT3 D835E, NPM1, NRAS) absent in the primary disease. Notably, both leukemias harbored distinct FLT3-TKD mutations, suggesting convergent evolution despite separate clonal origins. Absence of pathogenic variants in the cord blood supports de novo leukemogenesis. These findings implicate host or microenvironmental factors in driving leukemic transformation and highlight potential shared selective pressures in FLT3-TKD mutant AML.
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