Evidence map›Paper›PMID 42037720›Full record

ArticleFrontiers in neurology

Impact of hospital process reengineering on door-to-needle time for intravenous thrombolysis in acute ischemic stroke (PROMISE-CHINA): a multicenter prospective pre-post quasi-experimental study.

Dawei Dong, Longyan Lu, Niu He, Junrun Zhang, Ziran Wang, Haiqin Xia, Xuwen Sun, Yu Geng, Hui Liang, Xiaoyuan Niu and 32 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02631317 (Hospital Processes Reengineering of Intravenous Thrombolysis in Acute Ischemic Stroke in China), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02631317 completednot on this map

Hospital Processes Reengineering of Intravenous Thrombolysis in Acute Ischemic Stroke in China

Typeobservational_patient_registrySponsorFirst Affiliated Hospital of Jinan UniversityRan2014 to 2015Enrolled2,178ConditionsIschemic Stroke, Adverse Effect of Thrombolytic Drugs, SequelaArmsAdvance hospital notification by EMS, stroke team notification, key performance indicators feedback form, standard informed consent procedures, performance of thrombolysis at CT-room
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Dawei Dong *Department of Neurology and Stroke Center, the First Affiliated Hospital, Jinan University, Guangzhou, China.
Longyan Lu *Department of Neurology and Stroke Center, the First Affiliated Hospital, Jinan University, Guangzhou, China.
Niu He *Department of Neurology and Stroke Center, the First Affiliated Hospital, Jinan University, Guangzhou, China.
Junrun ZhangDepartment of Neurology and Stroke Center, the First Affiliated Hospital, Jinan University, Guangzhou, China.
Ziran WangEmergency Department, Linyi People's Hospital, Linyi, China.
Haiqin XiaDepartment of Neurology, The Six Hospital of Shanxi Medical University, Taiyuan, China.
Xuwen SunDepartment of Neurology, Yantai Yuhuangding Hospital, Yantai, China.
Yu GengDepartment of Neurology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Hui LiangDepartment of Neurology, Yantaishan Hospital, Yantai, China.
Xiaoyuan NiuDepartment of Neurology, The First Hospital of Shanxi Medical University, Taiyuan, China.
Meng ZhangDepartment of Neurology, Daping Hospital & Research Institute of Surgery, The Army Military Medical University, Chongqing, China.
Dongjuan XuDepartment of Neurology, Dongyang People's Hospital, Wenzhou Medical University, Jinhua, China.
Ning LiDepartment of Neurology, Tieying Hospital of Fengtai District, Beijing, China.
Jianhua LiDepartment of Neurology, First Hospital of Fangshan District, Beijing, China.
Wanhua WangDepartment of Neurology, The First People's Hospital of Kunshan, Suzhou, China.
Min ZhangDepartment of Neurology, Qingdao Municipal Hospital, Qingdao, China.
Zhong ZhangDepartment of Neurology, The Third People's Hospital of Chengdu, Chengdu, China.
Yongjun CaoDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Li SunDepartment of Neurology, Qingdao Central Hospital, Qingdao University, Qingdao, China.
Junshan ZhouDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Weirong LiDepartment of Neurology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China.
Peilan LiEmergency Department, Beijing Boai Hospital & China Rehabilitation Research Center, Beijing, China.
Jianhui FuDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Wei QiuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University Lingnan Hospital, Guangzhou, China.
Yanzhong XueDepartment of Neurology, Linyi Central Hospital, Linyi, China.
Yumin LiuDepartment of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jinli ZhangDepartment of Neurology, The People's Liberation Army No. 263 Hospital, Beijing, China.
Weiwen QiuDepartment of Neurology, Lishui Central Hospital, Lishui, China.
Yan XingDepartment of Neurology, Aviation General Hospital of China Medical University & Beijing Institute of Translational Medicine, Chinese Academy of Sciences, Beijing, China.
Zhengqi LuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Fuling LiuDepartment of Neurology, Pingdu People's Hospital, Qingdao, China.
Shixia WangDepartment of Neurology, Neimenggu Baogang Hospital, Inner Mongolia Medical University, Baotou, China.
Jilai LiDepartment of Neurology, Aerospace Central Hospital, Beijing, China.
Dawei ZangDepartment of Neurology, Tianjin First Central Hospital of Tianjin Medical University, Tianjin, China.
Junyan LiuDepartment of Neurology, Third Hospital of Hebei Medical University, Shijiazhuang, China.
Juan FengDepartment of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
Zhengshe BaoDepartment of Neurology, Beijing Yanhua Hospital, Beijing, China.
Suping ZhangDepartment of Neurology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, China.
Yongjun WangBeijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiufeng XinDepartment of Neurology and Stroke Center, the First Affiliated Hospital, Jinan University, Guangzhou, China.
Huili ZhuDepartment of Neurology and Stroke Center, the First Affiliated Hospital, Jinan University, Guangzhou, China.
Anding XuDepartment of Neurology and Stroke Center, the First Affiliated Hospital, Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Intravenous thrombolytic therapy significantly improves the prognosis of patients with acute ischemic stroke in a time-dependent manner. This study aims to evaluate the effectiveness of hospital process reengineering in reducing delays to intravenous thrombolysis in patients with acute ischemic stroke. Methods: This multicenter, prospective, nonrandomized quasi-experimental (pre-post) study included patients with acute ischemic stroke presenting within 3.5 h of symptom onset. Hospital process reengineering involved key measures such as pre-notification by emergency medical services, simultaneous activation of a multidisciplinary team, standardized communication, and regular feedback to streamline workflows. Data from pre-intervention (July 1-September 30, 2014, Q1) were compared to post-intervention (October 1, 2014-June 30, 2015, Q2-Q4). The primary outcomes included the door-to-needle time and its changes, the proportion of patients receiving intravenous thrombolysis, and the percentage of patients achieving a door-to-needle time <60 min. Results: A total of 2,059 acute ischemic stroke patients were included, with 535 in the pre-intervention period and 1,524 in the post-intervention period. Following the intervention, the median door-to-needle time significantly decreased from 73 to 63 min ( Conclusion: Hospital process reengineering significantly improved door-to-needle time, highlighting the importance of optimizing workflows in acute stroke care. Although this study was conducted a decade ago, its findings continue to offer valuable insights and practical implications for underdeveloped regions and countries. Clinical trial registration: Clinicaltrials.gov, NCT02631317 (https://clinicaltrials.gov/study/NCT02631317).

Indexed as

acute ischemic strokedoor-to-needle timehealthcare qualityhospital processes reengineeringrate of thrombolysis

Identifiers

PMID42037720
PMCPMC13105936

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.