ArticleFrontiers in neurology
Protocol for a multicenter prospective sequential intervention study: the effect of adaptive closed-loop postural training on gait disorders in hemiparetic stroke patients.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Stroke often leads to hemiparetic gait, which negatively affects the quality of life and increases socioeconomic burdens. Conventional therapies have limited effectiveness in improving gait. Postural regulation deficits are a key factor contributing to gait disorders. The Gusu Constraint Standing Training (GCST), a novel posture adjustment approach, shows promise in improving central gait disorders. We hypothesize that GCST optimizes gait in hemiparetic stroke patients by enhancing their postural adaptation criticality and improving gait control through the common neural pathways and nodes shared by posture and gait. However, the specific effects and underlying mechanisms of GCST require further study. Methods and analysis: This multicenter, prospective, sequential study will recruit 180 hemiparetic stroke patients (recovery phase: 3-6 months; chronic phase: ≥6 months post-stroke) across four hospitals, along with 30 healthy controls. GCST is divided into a structured, stepwise intervention (steps A-E) implemented sequentially based on predefined performance criteria. Assessments will be conducted at baseline, after the completion of each intervention step, and at follow-ups. The primary outcome is the minimal knee flexion angle of the hemiparetic limb during the swing phase, quantified using the three-dimensional gait analysis. Secondary outcomes include gait, postural, neuromuscular, and functional measures. Outcome assessors will be blinded to participants' stroke phase. Longitudinal data will be analyzed using linear mixed-effects models. Healthy controls will provide normative reference values. Ethics and dissemination: Approved by each hospital's ethics committees, the study will require informed consent from participants. The results will be shared through academic conferences and peer-reviewed journals while ensuring participant confidentiality. Clincial trial registration: https://www.chictr.org.cn/showproj.html?proj=235182, Identifier ChiCTR2400094903.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.