ArticleFrontiers in neurology
Adjunctive PC6 magnetic stimulation with rTMS over left DLPFC for post-stroke cognitive impairment: a protocol for fNIRS-fMRI randomized controlled trial.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Background: Post-stroke cognitive impairment (PSCI) is a common stroke complication, significantly reducing patients' quality of life and increasing caregiving burden. Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (L-DLPFC) improves cognition but with limited efficacy. Stimulation of Neiguan (PC6), a key acupoint in traditional Chinese medicine, modulates cognition-related brain networks. Objective: To compare cognitive improvement and brain network remodeling in PSCI patients who receive rTMS over the L-DLPFC combined with (1) PC6 magnetic stimulation (MAG), (2) PC6 acupuncture (ACU), or (3) PC6 sham magnetic stimulation (SHM). Methods: This three-arm randomized controlled trial will enroll 105 patients with PSCI, randomly allocated 1:1:1 to the MAG ( Conclusion: This study will provide the first randomized controlled evidence for acupoint magnetic stimulation in PSCI, demonstrating that adding MAG to L-DLPFC rTMS confers additional cognitive benefits. Its mechanism in reshaping brain networks will be elucidated via fNIRS-fMRI, which is expected to accelerate clinical translation of non-pharmacological interventions. Clinical trial registration: https://www.chictr.org.cn/, identifier ChiCTR2400090768.
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