ArticleOpen life sciences2026
Changes in gut microbiota before and after treatment in patients with primary hypothyroidism.
Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aims to analyze the differences in gut microbiota of patients with primary hypothyroidism before and after treatment and their correlations with clinical indicators. A total of 20 newly diagnosed primary hypothyroidism patients were selected for the study. These patients were treated with levothyroxine sodium (L-T4) for 12 weeks, and fecal samples were collected before and after treatment. Concurrently, fecal samples from 20 healthy controls were also collected. High-throughput 16sRNA sequencing was conducted to analyze the composition of gut microbiota in each group. At the phylum level, the abundance of Bacteroidetes decreased in patients with primary hypothyroidism. After treatment, the abundance of Bacteroidetes increased, while the abundance of Proteobacteria and Desulfobacterota decreased. At the genus level, the abundance of
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