Evidence map›Paper›PMID 42037562›Full record

ArticleChemistry & biodiversity2026

Enzymatic Poly(gallic acid)-grafted L-Histidine Reduces Cell Inflammation and Oxidative Stress: In Silico and In Vitro Studies.

Carmen G Hernández-Valencia, Iris N Serratos, Carlos M Torre-Morales, Rosa Isela Ortiz-Huidobro, Alfredo Vázquez, José Pedraza-Chaverri, Valentín Martínez-López, Javier Fernández-Torres, Roberto Sánchez-Sánchez, Yessica Zamudio-Cuevas and 1 more

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carmen G Hernández-ValenciaFacultad de Química, Departamento de Alimentos y Biotecnología, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, México.
Iris N SerratosDepartamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, Iztapalapa, Ciudad de México, Mexico.
Carlos M Torre-MoralesFacultad de Química, Departamento de Alimentos y Biotecnología, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, México.
Rosa Isela Ortiz-HuidobroFacultad de Química, Departamento de Alimentos y Biotecnología, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, México.
Alfredo VázquezFacultad de Química, Departamento de Química Orgánica, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, México.
José Pedraza-ChaverriFacultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, México.
Valentín Martínez-LópezUnidad de Ingeniería de Tejidos Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra, Ciudad de México, México.
Javier Fernández-TorresLaboratorio de Liquido sinovial, Instituto Nacional de Rehabilitación, Luis Guillermo Ibarra Ibarra, Ciudad de México, México.
Roberto Sánchez-SánchezUnidad de Ingeniería de Tejidos Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra, Ciudad de México, México.
Yessica Zamudio-CuevasLaboratorio de Liquido sinovial, Instituto Nacional de Rehabilitación, Luis Guillermo Ibarra Ibarra, Ciudad de México, México.
Miquel GimenoFacultad de Química, Departamento de Alimentos y Biotecnología, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, México.ORCID https://orcid.org/0000-0003-2706-7048

Funding

DGAPA-UNAM IN200126DGAPA-UNAM IN202725
6 · The paper itself

Abstract

Enzyme-mediated poly(gallic acid) (PGAL) exhibits intrinsic anti-inflammatory and antioxidant properties; in this study, its chemical functionality was enhanced by microwave-assisted grafting of L-histidine to obtain PGAL-His. Incorporation of the amino acid into the PGAL backbone reached 33.24 ± 0.74 mol%. Molecular docking and binding energy calculations were used to model PGAL-His interactions, revealing that the NH

Indexed as

Anti-Inflammatory AgentsAntioxidantsGallic AcidHistidineInflammationOxidative StressPolymersCytokinesHumansMolecular Docking SimulationReactive Oxygen SpeciesTHP-1 CellsAnti-Inflammatory AgentsAntioxidantsCytokinesGallic AcidHistidinePolymersReactive Oxygen Speciescomputational modelelectrostatic interactionsl‐histidineoxidative stresspoly(gallic acid)proinflammatory cytokines

Identifiers

PMID42037562
PMCPMC13112469

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.