Evidence map›Paper›PMID 42037549›Full record

Trial reportAging cell2026

Short-Term Dietary Intervention Alters Physiological Profiles Relevant to Ageing.

Caitlin J Andrews, Rosilene V Ribeiro, Alison Gosby, David G Le Couteur, David Raubenheimer, Jian Tan, Stephen J Simpson, Alistair M Senior

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caitlin J AndrewsSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Rosilene V RibeiroSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Alison GosbySchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
David G Le CouteurCharles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-4227-5817
David RaubenheimerSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Jian TanCharles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Stephen J SimpsonSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Alistair M SeniorSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.

Funding

Australian Research Council FT230100240Faculty of Science Research Stipend Scholarship SC3852University of Sydney
6 · The paper itself

Abstract

Ageing is a complex process influenced by modifiable factors such as diet, which may accelerate or decelerate physiological decline. While chronological age increases uniformly, biological ageing varies between individuals, reflecting differences in health status and the resilience of biological systems. The Klemera-Doubal Method (KDM), a composite biomarker-based index often used as an estimate of biological age, has been associated with morbidity and mortality in large cohorts. This study examined whether dietary manipulation of protein source and macronutrient composition affects KDM estimates in older adults. We analysed data from the Nutrition for Healthy Living study, a 2 × 2 factorial dietary intervention trial involving 104 participants aged 65-75 years. Participants were randomised to one of four diets: omnivorous/high-fat (OHF), omnivorous/high-carbohydrate (OHC), semi-vegetarian/high-fat (VHF) or semi-vegetarian/high-carbohydrate (VHC). KDM-derived δAge (the difference between KDM- and chronological-age) was calculated before and after a 4-week intervention. The OHF group, most like participants' baseline diets, showed no meaningful change in δAge. Compared to OHF, participants in the OHC group showed a significant reduction in δAge. The VHF and VHC groups showed similar reductions in δAge, relative to OHF, though not all reached statistical significance. KDM-derived δAge appears responsive to dietary change within 4 weeks and may offer a useful proxy for evaluating shifts in physiological status. Caution is warranted in interpreting such changes as evidence of biological age reversal as observed shifts may reflect acute physiological responsiveness to dietary inputs rather than altered ageing trajectories. Longer-term treatment would be needed to assess changes in age-related disease risks.

Indexed as

AgingDietAgedFemaleHumansMale

Identifiers

PMID42037549
PMCPMC13112187

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.