Evidence map›Paper›PMID 42037495›Full record

ArticlePsychological medicine2026

Cognitive reserve in non-affective first-episode psychosis: contributions of polygenic scores, early clinical features, and environment.

M Florencia Forte, Àlex G Segura, Maria Serra-Navarro, Gisela Mezquida, Carla Torrent, Javier Gonzalez-Peñas, Sergi Mas, Eduard Vieta, Alvaro Andreu-Bernabeu, Manuel J Cuesta and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

M Florencia ForteBipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, Barcelona, Catalonia, Spain.
Àlex G SeguraBipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, Barcelona, Catalonia, Spain.
Maria Serra-NavarroBipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, Barcelona, Catalonia, Spain.
Gisela MezquidaBarcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain.
Carla TorrentBipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, Barcelona, Catalonia, Spain.
Javier Gonzalez-PeñasBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Madrid, Spain.
Sergi MasBarcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain.
Eduard VietaBipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, Barcelona, Catalonia, Spain.ORCID https://orcid.org/0000-0002-0548-0053
Alvaro Andreu-BernabeuBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Madrid, Spain.
Manuel J CuestaDepartment of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain.
Anna ManéBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Madrid, Spain.
Elena de la SernaBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Madrid, Spain.
Kelly AllottOrygen, Parkville, Australia.
Miquel BernardoBarcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain.
Silvia AmorettiBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Madrid, Spain.
PEPs Group

Funding

Instituto de Salud Carlos III PI08/0208; PI11/00325; PI14/00612
6 · The paper itself

Abstract

backgroundCognitive reserve (CR) is a protective factor in first-episode psychosis (FEP), influencing cognitive, clinical, and functional outcomes. CR is shaped by a combination of genetic, clinical, and environmental factors, yet the extent of their respective contributions remains unclear. This study investigates the influence of polygenic risk scores (PRS), clinical and environmental variables on CR in FEP.

methodsA cohort of 174 individuals with non-affective FEP, aged 25.5 (SD=5.3), was analyzed. CR was assessed using a socio-behavioral proxy. PRS for educational attainment (PRS

resultsPRS

conclusionsThese findings highlight the role of precision psychiatry in better understanding CR. Early identification of individuals with earlier onset, family history of psychosis, and lower genetic predisposition to educational attainment may help characterize those with lower CR.

Indexed as

Cognitive ReservePsychotic DisordersAdultAge of OnsetEducational StatusFemaleGenetic Risk ScoreHumansIntelligenceMaleMultifactorial InheritanceSchizophreniaYoung Adultage at onsetclinical featurescognitioncognitive reserveearly stageseducational attainmentenvironmental factorsfamily history of psychosisfirst-episode psychosisgeneticspolygenic risk scorespsychosis

Identifiers

PMID42037495
PMCPMC13125930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.