Evidence map›Paper›PMID 42037422›Full record

ArticleJournal of clinical microbiology2026

Cytokine and chemokine profiles linked to early severity of scrub typhus: multicenter validation of soluble PD-L1.

Dachuan Lin, Gaoyu Wang, Liyuan Zhang, Meng Chang, Hua Pei, Xiaoyuan Hu, Ruoyan Peng, Chuanning Tang, Yijia Guo, Siqi Chen and 12 more

Abstract readMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Dachuan Lin *Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.ORCID 0000-0002-4404-7391
Gaoyu Wang *Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.
Liyuan Zhang *Department of Infectious Diseases, the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Meng Chang *Department of Clinical Laboratory, Center for laboratory Medicine, Hainan Women and Children's Medical Center, Hainan Medical University, Haikou, Hainan, China.
Hua PeiDepartment of Infectious Diseases, the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Xiaoyuan HuHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.
Ruoyan PengHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.
Chuanning TangHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.
Yijia GuoHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.
Siqi ChenHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.
Nan GeHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.
Wenjun TianHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.
Fahui WangDepartment of Infectious Diseases, the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Yongguo DuDepartment of Infectious Diseases, the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Shannan WuAnimal and Plant Quarantine Center Haikou Customs District, Haikou, Hainan, China.
Yueping WangDepartment of Infectious Diseases, the First affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Long SunDepartment of Infectious Diseases, the First affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Biao WuDepartment of Infectious Diseases, Hainan General Hospital, Haikou, Hainan, China.
Kwok-Yung YuenHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.ORCID 0000-0001-8700-4570
Jasper Fuk-Woo ChanHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.ORCID 0000-0001-7996-1119
Min LiaoDepartment of Infectious Diseases, Hainan General Hospital, Haikou, Hainan, China.ORCID 0009-0008-6721-1052
Feifei YinHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases and Academician Workstation of Hainan Province, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of basic medical sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, China.ORCID 0000-0001-6195-0614

Funding

National Natural Science Foundation of China 82060378
6 · The paper itself

Abstract

Early identification of patients at risk of developing severe disease remains a clinical challenge for scrub typhus. We aimed to identify serum cytokine profiles associated with disease severity and validate potential biomarkers for early risk stratification of patients with scrub typhus. We conducted a retrospective multicenter study to analyze serum cytokine/chemokine profiles and clinical data of 51 scrub typhus patients and 13 control patients at presentation to the hospital. We further performed longitudinal monitoring of the cytokine/chemokine dynamics in 11 of these patients. The findings were then validated in two different hospitals ( IMPORTANCE: Scrub typhus, caused by

Indexed as

B7-H1 AntigenChemokinesCytokinesScrub TyphusAdultAgedAged, 80 and overBiomarkersFemaleHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexB7-H1 AntigenBiomarkersCD274 protein, humanChemokinesCytokinescytokinesdisease severityscrub typhussPD-L1

Identifiers

PMID42037422
PMCPMC13251376

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.