Evidence map›Paper›PMID 42037406›Full record

ArticleJournal of virology2026

Griffithsin-mediated inhibition of cellular entry of hemorrhagic fever viruses and insights into its mechanisms.

Takeshi Saito, Wakako Furuyama, Devinda S Muthusinghe, Yannick Munyeku-Bazitama, Takanari Hattori, Mami Okabe, Takeshi Yokoyama, Yoshikazu Tanaka, Ryuichi Sakai, Yasuteru Sakurai and 11 more

Abstract read
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In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Takeshi Saito *Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0002-6908-0702
Wakako Furuyama *National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan.ORCID 0000-0001-7163-6960
Devinda S Muthusinghe *National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan.
Yannick Munyeku-BazitamaDivision of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.ORCID 0000-0001-8303-318X
Takanari HattoriDivision of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Mami OkabeGraduate School of Life Sciences, Tohoku University, Sendai, Japan.
Takeshi YokoyamaGraduate School of Life Sciences, Tohoku University, Sendai, Japan.
Yoshikazu TanakaGraduate School of Life Sciences, Tohoku University, Sendai, Japan.ORCID 0000-0002-7893-3236
Ryuichi SakaiHokkaido University Faculty and Graduate School of Fisheries Sciences, Hakodate, Japan.
Yasuteru SakuraiNational Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan.
Miako SakaguchiInstitute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Rika TsukagoshiDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Noelia S Coronado BarriosDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Thomas TipihLaboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Kyle RosenkeLaboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Andrea MarziLaboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.ORCID 0000-0003-0186-9587
Manabu IgarashiDivision of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Shuzo UrataNational Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan.ORCID 0000-0003-0710-2272
Junki MaruyamaDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0003-0088-4793
Asuka NanboNational Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan.ORCID 0000-0001-8764-1350
Ayato TakadaDivision of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.ORCID 0000-0003-2464-6642

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Griffithsin (GRFT), a lectin derived from the red algae IMPORTANCE: Emerging and re-emerging infectious diseases, including viral hemorrhagic fevers, pose a major global health threat due to their potential for widespread outbreaks. Currently, treatment options for such diseases are limited and often ineffective against newly emerging viruses. Here, we demonstrate that Griffithsin (GRFT), a naturally derived lectin from red algae, inhibits the entry of multiple hemorrhagic fever viruses into host cells. By blocking key processes of the viral entry mediated by envelope glycoproteins, lectins such as GRFT can exhibit broad antiviral activity that could potentially overcome the limitations of existing treatments against emerging viruses. Our findings emphasize that targeting sugar chains and adjacent structures on viral glycoproteins with GRFT could provide a therapeutic strategy against diverse viral species. Such an approach is particularly valuable for newly emerging viruses for which specific countermeasures have not yet been established.

Indexed as

Antiviral AgentsHemorrhagic Fevers, ViralPlant LectinsVirus InternalizationAnimalsCell LineChlorocebus aethiopsEbolavirusHemorrhagic Fever Virus, Crimean-CongoHumansLassa virusLujo virusMarburgvirusVero CellsViral Envelope ProteinsAntiviral Agentsgriffithsin protein, GriffithsiaPlant LectinsViral Envelope ProteinsantiviralCrimean-Congo hemorrhagic fever virusEbola virusentryGriffithsinhemorrhagic fever virusLassa virusLujo virusMarburg virus

Identifiers

PMID42037406
PMCPMC13185625

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.