ArticleMycoses2026
A Novel Hyphal Suspension Approach for MIC Testing of Mould Fungi.
Article in Mycoses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundFilamentous fungi cause a wide range of superficial and invasive infections, and antifungal susceptibility assay is essential for guiding effective therapy. Standard broth microdilution methods rely on microconidia-based inocula; however, many clinically important moulds produce insufficient microconidia due to intrinsic characteristics or culture conditions, limiting the applicability of conventional testing and often necessitating empirical treatment.
objectivesTo overcome this limitation, we developed an alternative method using precisely quantified mycelial cell suspensions for MIC determination.
methodsThe method was evaluated using 115 fungal strains and compared with traditional microconidia-based testing.
resultsHigh concordance was observed between the two approaches, with agreement rates of 90% or higher across three common dermatophytes causing tinea infections and three representative fungi responsible for invasive infections.
conclusionsThis mycelial-based approach provides a reliable and practical alternative for antifungal susceptibility testing of poorly sporulating moulds and may improve the efficiency and accessibility of MIC testing in clinical laboratories.
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