In one paragraphArticle in Circulation. Genomic and precision medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
26 authors.
Daeeun KimDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.).ORCID 0000-0002-9387-0739 Hannah G PolikowskyDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.).ORCID 0000-0001-7226-9752 Heather M HighlandDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.).ORCID 0000-0002-3583-8239 Hung-Hsin ChenDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.).ORCID 0000-0002-1921-2797 Wanying ZhuDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.).ORCID 0000-0002-2673-3048 Xinruo ZhangDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.).ORCID 0000-0001-5789-4592 Madeline G GillmanDepartment of Genetics, School of Medicine, University of North Carolina at Chapel Hill (D.K., M.G.G., L.M.R.).
Elizabeth G FrankelDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.).ORCID 0009-0001-4764-612X Rashedeh RoshaniDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.).ORCID 0009-0001-2696-2852 Joshua M LandmanDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.).ORCID 0000-0003-2431-6053 Yujie WangDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.).ORCID 0000-0002-1087-2182 Kristin L YoungDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.).ORCID 0000-0003-0070-6145 Mohammad Yaser AnwarDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.).ORCID 0000-0002-2349-8214 Mohanraj KrishnanDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.).
Victoria L BuchananDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.).ORCID 0000-0001-9943-9950 Sonja I BerndtUS Dept of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD (S.I.B., J.D.A.).ORCID 0000-0001-5230-0652 Joshua D AriasUS Dept of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD (S.I.B., J.D.A.).ORCID 0000-0001-6545-6656 Laura M RaffieldDepartment of Genetics, School of Medicine, University of North Carolina at Chapel Hill (D.K., M.G.G., L.M.R.).ORCID 0000-0002-7892-193X Absalon D GutierrezDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Texas Health Science Center at Houston McGovern Medical School (A.D.G.).ORCID 0000-0002-5488-7028 Faraz BishehsariGastroenterology Research Center, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine (F.B.).ORCID 0000-0001-5644-2586 Miryoung LeeDepartment of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Brownsville, TX (H.M.H., Y.W., K.L.Y., V.L.B., M.L., J.B.M.C., S.P.F.-H., K.E.N.).ORCID 0000-0003-4088-304X Joseph B McCormickDepartment of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Brownsville, TX (H.M.H., Y.W., K.L.Y., V.L.B., M.L., J.B.M.C., S.P.F.-H., K.E.N.).ORCID 0000-0002-5844-8102 Susan P Fisher-HochDepartment of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Brownsville, TX (H.M.H., Y.W., K.L.Y., V.L.B., M.L., J.B.M.C., S.P.F.-H., K.E.N.).ORCID 0000-0002-7894-5114 Jennifer E BelowDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN (H.G.P., H.-H.C., W.Z., E.G.F., R.R., J.M.L., J.E.B.).ORCID 0000-0002-1346-1872 Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.).ORCID 0000-0002-8903-0366 Mariaelisa GraffDepartment of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC (D.K., H.M.H., X.Z., Y.W., K.L.Y., M.Y.A., M.K., V.L.B., K.E.N., M.G.).ORCID 0000-0001-6380-1735 Funding
Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3MLeveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9MPAGE III: Population Architecture using Genomics and EpidemiologyR01HG010297 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI GIGNOUX, CHRISTOPHER R, MATISE, TARA C. · 2019 to 2022
$6.5MGene-Environment Interactions and Weight GainR01HD057194 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY, NORTH, KARI E. · 2008 to 2019
$5.9MHispanic Latino Lipid ConsortiumR01HL142302 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer Below, JOSEPH MCCORMICK · 2018 to 2026
$5.8MIntegrative Approaches to Identifying Function and Clinical Significance of Adiposity Susceptibility GenesR01DK122503 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Anne Justice, Ching-Ti Liu · 2020 to 2026
$4.5MDevelopment of a precision medicine platform for circadian based therapeutics in pancreatic cancerR01CA279487 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BISHEHSARI, FARAZ · 2022 to 2025
$3.6MPharmacogenetics of the Response to GLP-1 in Mexican-Americans with PrediabetesR01DK127084 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GUTIERREZ, ABSALON DENNIS · 2021 to 2025
$3.5MMulti-omics for obesity-associated liver disease in a high-risk population cohortU01CA288325 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jennifer Below, JOSEPH MCCORMICK · 2023 to 2026
$3.3MLeveraging Hispanic/Latino diversity to map and characterize cardiovascular disease lociR01HL163262 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Lindsay Fernandez-Rhodes, Mariaelisa Graff · 2023 to 2026
$2.9MGenomic, transcriptomic, and metabolic effects on skeletal health in Mexican AmericansR01AG078452 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MIRYOUNG LEE, Nahid J. Rianon · 2023 to 2026
$2.7MIntegrative multi-omics for discovery of molecular pathways associated with diabetic retinopathyR01EY036258 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer Below, SUSAN P FISHER-HOCH · 2024 to 2026
$2.3MNCI NIH HHS R01 CA279487NCI NIH HHS U01 CA288325NEI NIH HHS R01 EY036258NHGRI NIH HHS R01 HG010297NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL143885NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R01 HL163262NIA NIH HHS R01 AG078452NIA NIH HHS U01 AG086145NICHD NIH HHS R01 HD057194NIDDK NIH HHS R01 DK122503NIDDK NIH HHS R01 DK127084NIDDK NIH HHS R01 DK139598
6 · The paper itselfAbstract
backgroundWhile GWAS (genome-wide association studies) have identified over 1000 obesity-associated loci, their functional impact on gene expression remains unclear. Moreover, many studies have not fully captured the genetic architecture of obesity in high-risk populations or considered the complexity of adiposity beyond traditional measures. To address these gaps, this study explores the genetic and transcriptomic pathways of obesity using diverse obesity phenotypes in a high-risk population.
methodsWe analyzed genomic and whole-blood transcriptomic data from the CCHC (Cameron County Hispanic Cohort), performing GWAS on 13 obesity-related traits. Differential expression analysis was conducted for genes near GWAS-identified single nucleotide polymorphisms (
resultsGWAS identified 486 trait associations, including 6 genome-wide significant (
conclusionsThis integrative genomic-transcriptomic analysis uncovers 2 novel candidate genes for obesity and underscores the critical need for involving all populations and comprehensive adiposity measures in obesity research. By expanding beyond body mass index in a Hispanic/Latino population, we move closer to a deeper and more inclusive understanding of obesity's genetic architecture.
Indexed as
Hispanic or LatinoMitogen-Activated Protein Kinase 11ObesityPeriod Circadian ProteinsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideQuantitative Trait LociTranscriptomeMitogen-Activated Protein Kinase 11PER1 protein, humanPeriod Circadian Proteinsadipositygene expressiongenome-wide association studyhispanic or latinoobesity
Identifiers
PMID42037308
PMCPMC13127804
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