Evidence map›Paper›PMID 42037228›Full record

SynthesisCancer medicine2026

A Systematic Review on the Role of Postoperative Radiotherapy in Pelvic Ewing Sarcoma.

Angela Hong, Tracy Lim, Helen Lo, Vivek A Bhadri, Joanna Connor, Peter Grimison, Smaro Lazarakis, Jeremy Lewin, Jasmine Mar, Wayne Nicholls and 7 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Angela HongFaculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-3668-243X
Tracy LimDepartment of Radiation Oncology, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.
Helen LoMid North Coast Cancer Institute, Port Macquarie, New South Wales, Australia.
Vivek A BhadriFaculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia.
Joanna ConnorAuckland District Health Board, Auckland, New Zealand.
Peter GrimisonFaculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia.
Smaro LazarakisThe Royal Melbourne Hospital, Parkville, Victoria, Australia.
Jeremy LewinDepartment of Cancer Medicine, Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0002-4305-117X
Jasmine MarAustralia and New Zealand Sarcoma Association, Melbourne, Victoria, Australia.
Wayne NichollsOncology Services Group, Queensland Children's Hospital, South Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0003-0926-526X
Lisa OrmeChildren's Cancer Centre, the Royal Children's' Hospital Melbourne, Parkville, Victoria, Australia.
Marianne B PhillipsDepartment Oncology, Haematology and Tissue & Cellular Therapy, Perth Children's Hospital, Perth, Western Australia, Australia.
Stephen R ThompsonFaculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia.
Iain WardChristchurch Hospital, Christchurch, New Zealand.
Mark WinstanleyStarship Paediatric Blood & Cancer Centre, Auckland, New Zealand.
Julie CayrolThe Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0001-5211-1165
Natacha OmerOncology Services Group, Queensland Children's Hospital, South Brisbane, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ewing Sarcoma of the pelvis has poorer outcomes than other anatomical sites, with complex anatomy often precluding resection with wide margins. The role of postoperative radiotherapy (RT) in improving outcomes remains undefined. A systematic review using Medline, Embase and Cochrane databases (1972-April 2024) evaluated postoperative RT's impact on local recurrence, event-free survival and overall survival. Twenty-nine retrospective studies (21 to 296 patients) met inclusion criteria, with 28 rated good quality. Seven of 14 studies showed improved local control with postoperative RT. Ten studies reported consistent but non-significant trends favoring postoperative RT for event-free survival. Nineteen studies reported mixed overall survival findings; the Euro-EWING 99 trial showed significantly improved 5-year survival (72% vs. 47%, p = 0.024), while others showed conflicting results. Postoperative RT should be considered for high-risk features including poor response to induction chemotherapy, large tumour volume (> 200 mL) and positive margins. Clinical trial participation should be encouraged. Trial Registration: PROSPERO registration number: CRD42021291665.

Indexed as

Bone NeoplasmsPelvic NeoplasmsSarcoma, EwingHumansNeoplasm Recurrence, LocalRadiotherapy, AdjuvantEwing sarcomaguidelinespelvic Ewingradiotherapysarcoma

Identifiers

PMID42037228
PMCPMC13112018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.