Evidence map›Paper›PMID 42037002›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2026

Elevated Serum Neurofilament Light Chain Is Associated With Systemic Inflammation in Very Preterm Infants.

E-V Kivivuori, S-K Herukka, S Kärkkäinen, T Kokkola, J Kirjavainen, U Sankilampi

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Article in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

E-V KivivuoriDepartment of Pediatrics, Kuopio University Hospital, Kuopio, Finland.ORCID https://orcid.org/0009-0008-2986-8141
S-K HerukkaInstitute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
S KärkkäinenInstitute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
T KokkolaInstitute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0002-3303-3912
J KirjavainenDepartment of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
U SankilampiDepartment of Pediatrics, Kuopio University Hospital, Kuopio, Finland.

Funding

Päivikki ja Sakari Sohlbergin Säätiöthe Association of Friends of the University Children's Hospitals
6 · The paper itself

Abstract

aimNeurofilament light chain (NFL) and glial fibrillary acidic protein (GFAP) are known biomarkers of brain injury in adults, but their significance in very preterm (VPT) infants remains unclear. Given the strong link between inflammation, oxidative stress, and brain injury in this population, we investigated associations between NFL, GFAP, and inflammatory and oxidative stress markers in VPT infants.

methodsAs part of the prospective Finnish PreBaby study on metabolism in VPT infants, serum NFL and GFAP levels were measured at three timepoints from birth to term-equivalent age (TEA) to assess their associations with IL-6 protein levels depicting inflammation, oxidative stress marker urinary 8-isoprostane, and postmenstrual age (PMA).

resultsSerum NFL levels showed a strong positive correlation with IL-6 levels (Spearman correlation coefficient 0.784, p < 0.001). Higher NFL concentrations were associated with lower PMA and decreased towards TEA. A weaker correlation was observed between NFL and the oxidative stress marker 8-isoprostane. Serum GFAP levels were not associated with inflammation.

conclusionsSerum levels of neurofilament light chain are linked to inflammation in very preterm infants. The potential of NFL as an early biomarker of brain injury, potentially guiding preventive interventions and therapy in very preterm infants, should be investigated further.

Indexed as

InflammationNeurofilament ProteinsBiomarkersDinoprostFemaleGlial Fibrillary Acidic ProteinHumansInfant, NewbornInterleukin-6MaleOxidative StressProspective StudiesBiomarkersDinoprostGFAP protein, humanGlial Fibrillary Acidic ProteinInterleukin-6neurofilament protein LNeurofilament Proteinsbrain injuryinflammationneurofilamentoxidative stresspreterm

Identifiers

PMID42037002
PMCPMC13371390

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