Evidence map›Paper›PMID 42036992›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

Cerebrovascular recovery drives restoration of neurometabolite levels after mild COVID-19.

Devin B Coe, Francesca Branzoli, Nicholas Shaff, Sephira G Ryman, Davin K Quinn, Henry C Lin, Erik B Erhardt, Arvind Caprihan, Dhruba P Adhikari, Dinesh K Deelchand and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Devin B CoeThe Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Francesca BranzoliINSERM U 1127, CNRS UMR 7225, The Paris Brain Institute, Sorbonne University, Paris, France.
Nicholas ShaffThe Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Sephira G RymanThe Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.ORCID 0000-0002-1758-3391
Davin K QuinnDepartment of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Henry C LinDepartment of Internal Medicine, Raymond G Murphy VA Medical Center, Albuquerque, NM, USA.
Erik B ErhardtDepartment of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, USA.
Arvind CaprihanThe Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Dhruba P AdhikariThe Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Dinesh K DeelchandDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
Alisha N ParadaDepartment of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Aleksandr BirgDepartment of Internal Medicine, Raymond G Murphy VA Medical Center, Albuquerque, NM, USA.
Harm J van der HornDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Haley E J PratherThe Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Natalie HoffmanThe Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Lizza H O'ConnellThe Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Andrei A VakhtinThe Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.ORCID 0009-0005-9482-1161

Funding

Research Education ComponentP30AG086404 · NIA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Tamar Ginossar · 2024 to 2026
$17.7M
Pilot Project Program (PPP)P30GM122734 · NIGMS · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2018 to 2022
$7.0M
University of New Mexico (UNM) Center for Brain Recovery and RepairP30GM159568 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Jessica D Richardson · 2025 to 2026
$3.4M
Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseasesR01NS133569 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Sephira Ryman · 2023 to 2026
$3.2M
Cognitive sequelae of cerebrovascular and gut dysfunction in post-acute COVID-19 syndrome.R01NS129407 · NINDS · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI Andrei A Vakhtin · 2023 to 2026
$2.9M
DOD HT9425-24-1-0742NIA NIH HHS P30 AG086404NIGMS NIH HHS P30 GM122734NIGMS NIH HHS P30 GM159568NINDS NIH HHS R01 NS129407NINDS NIH HHS R01 NS133569
6 · The paper itself

Abstract

SARS-CoV-2 infection can trigger broad acute-stage endothelial dysfunction that is often followed by neurocognitive post-acute sequelae (PASC) chronically. It is thus of interest to evaluate long-term post-infection cerebrovascular function dynamics and their effects of neuronal health. Using functional magnetic resonance imaging (fMRI), we examined cerebrovascular reactivity (CVR) magnitude and delay across a broad post-infection timeline (3-59 months) in 69 participants who previously had mild cases of COVID-19. We also assessed the relationships between CVR and neurometabolite markers of neuronal health using magnetic resonance spectroscopy (MRS) in the thalamic region and the corona radiata. Increasing time since infection (TSI) was associated with shorter CVR delay in global gray (GM) and white matter (WM), with no effects of TSI on CVR magnitude. Parcellation of the GM revealed TSI-dependent decreases in CVR delays in nine of the 10 examined GM regions. CVR delay was inversely related to total choline (tCho), creatine (tCr), and N-acetylaspartate (tNAA) levels in the thalamic region, but not in the corona radiata. The results suggest slower cerebrovascular reactivity follows mild COVID-19 and eventually resolves spontaneously, albeit on a protracted timeline. Further, improved levels of tCho, tCr, and tNAA in the GM are associated with this functional cerebrovascular recovery.

Indexed as

BrainCerebrovascular CirculationCOVID-19AdultAgedAspartic AcidCholineCreatineFemaleGray MatterHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedPost-Acute COVID-19 SyndromeAspartic AcidCholineCreatineCerebrovascular reactivity (CVR)COVID-19hypercapniamagnetic resonance spectroscopy (MRS)post-acute sequelae of COVID-19

Identifiers

PMID42036992
PMCPMC13121233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.