SynthesisActa paediatrica (Oslo, Norway : 1992)2026
Regional Brain Volume Differences Were Associated With Behavioural Outcomes in Children Born Preterm: A Systematic Review.
Synthesis in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Critical Methodological Gaps in Brain Volume Review: A Reader's Perspective?Acta paediatrica (Oslo, Norway : 1992) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimThis systematic review explored associations between brain structural volumes and behavioural outcomes in children born preterm up to 32 weeks of gestation.
methodsPubMed, PsycINFO, Scopus and Web of Science were searched for papers published in English from 1 January 2013 to 7 November 2023. Studies were included if they examined brain volumetric measures using magnetic resonance imaging and behavioural outcomes from 24 months to 12 years.
resultsThe search identified 388 records and eight were included. These covered 564 children born at 27-36 weeks, 55.7% of whom were male, with assessments conducted between 2.9 and 10.2 years of age. Three studies were conducted in USA, two in Sweden and one each in Norway, Australia and Switzerland. The findings indicated a higher prevalence of neurodevelopmental and emotional outcomes among children born preterm, particularly autism spectrum disorder, attention deficit hyperactivity disorder and anxiety symptoms. These outcomes were associated with reduced or altered volumes in limbic and subcortical brain regions, such as the amygdala and thalamus.
conclusionVolumetric brain differences were associated with behavioural outcomes and may have reflected early neurobiological vulnerability to later behavioural and emotional difficulties. These findings support early identification of children at risk and targeted intervention strategies.
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