Evidence map›Paper›PMID 42036798›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

The adherence of memory clinics to consensus recommendations for dementia diagnosis: A multicentric study in Italy.

Cristina Festari, Claudio Singh Solorzano, Stefania Orini, Eleonora Castagna, Matteo Cotta Ramusino, Fabrizia D'Antonio, Adolfo Di Crosta, Alessia Masòtino, Federico Massa, Alice Mazzonetto and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

18 authors.

Cristina FestariLaboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.ORCID 0000-0003-3597-5097
Claudio Singh SolorzanoDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
Stefania OriniCognitive Disorders and Dementia Rehabilitation Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Eleonora CastagnaDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Matteo Cotta RamusinoUnit of Behavioral Neurology and Dementia Research Center (DRC), IRCCS Mondino Foundation, Pavia, Italy.
Fabrizia D'AntonioDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Adolfo Di CrostaDepartment of Psychology, University G. d'Annunzio, Chieti-Pescara, Italy.
Alessia MasòtinoDepartment of Medicine and Aging Sciences, University G. d'Annunzio, Chieti-Pescara, Italy.
Federico MassaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Alice MazzonettoDepartment of Neuroscience, and Padua Neuroscience Center, University of Padova, Padua, Italy.
Massimiliano PaniguttiDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Noemi RavìDepartment of Neuroscience, and Padua Neuroscience Center, University of Padova, Padua, Italy.
Michela PievaniLaboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Laura BonanniDepartment of Medicine and Aging Sciences, University G. d'Annunzio, Chieti-Pescara, Italy.
Giuseppe BrunoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Annachiara CagninDepartment of Neuroscience, and Padua Neuroscience Center, University of Padova, Padua, Italy.
Roberto GattaDepartment of Clinical and Experimental Sciences, Università degli Studi di Brescia, Brescia, Italy.
Giovanni Battista FrisoniDivision of Geriatrics and Rehabilitation, Memory Centre, University Hospitals of Geneva, Geneva, Switzerland.

Funding

GE HealthcareItalian Ministry of HealthRoche Diagnostics
6 · The paper itself

Abstract

introductionQuantitative evaluations of how recommendations influence clinical practice are limited. This study assessed changes in the diagnostic pathways after the 2020 Italian Intersocietal Consensus Recommendations (IICR) for biomarker-based dementia diagnosis.

methodsMedical charts of new patients referred to three Italian memory clinics were reviewed for 2018 and 2019 (pre-IICR) and 2022 and 2023 (post-IICR). Sociodemographic and clinical data were extracted. Adherence to IICR was measured using an adherence index (AI, range 0-5). Deviations from recommended pathways were analyzed.

resultsWe analyzed 601 pathways in pre-IICR and 434 in post-IICR. Biomarker-based diagnoses increased from 23% to 41% post-IICR, with a significant redistribution of diagnostic categories and greater biomarker use. The AI increased modestly (2.09 ± 1.04 to 2.28 ± 1.04; p = 0.04), driven by improved neuropsychological assessment and biomarker selection (p < 0.001). Deviation analyses showed that adherence remained heterogeneous, with reduced biomarker use in older patients. DISCUSSION: Diagnostic practices partially aligned with IICR, reflecting a progressive shift toward standardized, biologically informed dementia diagnosis in Italian expert centers.

Indexed as

DementiaGuideline AdherenceAgedAged, 80 and overBiomarkersFemaleHumansItalyMaleNeuropsychological TestsBiomarkersdiagnosisneurocognitive disorderspracticerecommendationsvalidation study

Identifiers

PMID42036798
PMCPMC13111418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.