Evidence map›Paper›PMID 42036789›Full record

ArticleEuropean journal of immunology2026

Interferon-Regulatory Factor 4 Is Required Not Only for Induction but Also for Maintenance of the Th17 Phenotype.

Janis Patten, Prema Erramsetti, Addi Josua Romero Olmedo, Olaf Pinkenburg, Magdalena Huber, Michael Lohoff

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Janis PattenClinic for Hematology, Oncology and Immunology, Philipps-University Marburg, Marburg, Germany.
Prema ErramsettiClinic for Hematology, Oncology and Immunology, Philipps-University Marburg, Marburg, Germany.
Addi Josua Romero OlmedoClinic for Hematology, Oncology and Immunology, Philipps-University Marburg, Marburg, Germany.ORCID 0000-0001-7772-9746
Olaf PinkenburgMolecular Physiology, Philipps-University Marburg, Marburg, Germany.
Magdalena HuberInstitute of Systems Immunology, Philipps-University Marburg, Marburg, Germany.
Michael LohoffClinic for Hematology, Oncology and Immunology, Philipps-University Marburg, Marburg, Germany.ORCID 0000-0002-5204-4289

Funding

Deutsche Forschungsgemeinschaft (DFG) LO 396/8-2University Medical Center Giessen and Marburg 09/2023 MR
6 · The paper itself

Abstract

We previously showed that primary differentiation of naïve T cells is dependent on IRF4. Now we show that maintenance of already differentiated conventional and pathogenic Th17 cells is also dependent on IRF4.

Indexed as

Cell DifferentiationInterferon Regulatory FactorsTh17 CellsAnimalsInterferon Regulatory Factor-4MiceMice, KnockoutPhenotypeInterferon Regulatory Factor-4Interferon Regulatory Factorscytokineinterferon‐regulatory factor 4 (IRF4)interleukinmaintenanceTh17‐cell‐differentiation

Identifiers

PMID42036789
PMCPMC13111725

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.