Evidence map›Paper›PMID 42036773›Full record

Trial reportCancer medicine2026

Impact of the Oncologist's Recommendation on Exercise Levels and Quality of Life in Patients With Lung Cancer: The ORE Randomized Controlled Trial.

Alice Avancini, Lorenzo Belluomini, Diana Giannarelli, Jessica Insolda, Anita Borsati, Marco Sposito, Jessica Menis, Paolo Lavagnolo, Daniela Tregnago, Ilaria Trestini and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05497544 (A Randomized Controlled Trial to Evaluate the Impact of Oncologists 'Exercise Recommendation on the Exercise Levels in Lung Cancer Patients), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05497544 naunknown statusnot on this map

A Randomized Controlled Trial to Evaluate the Impact of Oncologists 'Exercise Recommendation on the Exercise Levels in Lung Cancer Patients

TypeinterventionalSponsorUniversita di VeronaRan2022 to 2025Enrolled60ConditionsLung CancerArmsExercise recommendation group, Exercise recommendation plus guidebook group
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Methodology of analysis of cognitive impairment in longitudinal randomized clinical trials in oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alice AvanciniSection of Oncology, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Verona, Italy.ORCID https://orcid.org/0000-0003-2439-4799
Lorenzo BelluominiSection of Oncology, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Verona, Italy.
Diana GiannarelliFondazione Policlinico Universitario A. Gemelli, IRCCS-Epidemiology & Biostatistic, Rome, Italy.
Jessica InsoldaSection of Oncology, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Verona, Italy.
Anita BorsatiDepartment of Neurosciences, Biomedicine and Movement Science, University of Verona, Verona, Italy.
Marco SpositoSection of Oncology, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Verona, Italy.
Jessica MenisDepartment of Medical Oncology, University Hospital of Verona, Verona, Italy.
Paolo LavagnoloDepartment of Neurosciences, Biomedicine and Movement Science, University of Verona, Verona, Italy.
Daniela TregnagoSection of Oncology, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Verona, Italy.
Ilaria TrestiniDietetic Service, Medical Direction, University Hospital of Verona (AOUI), Verona, Italy.
Federico SchenaDepartment of Neurosciences, Biomedicine and Movement Science, University of Verona, Verona, Italy.
Michele MilellaSection of Oncology, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-3826-5237
Sara PilottoSection of Oncology, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Verona, Italy.ORCID https://orcid.org/0000-0003-2229-4874

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough physical activity is associated with improved survival in lung cancer, most patients remain inactive. This study examined the impact of an oncologist's recommendation on exercise quantity, sedentary behavior, and quality of life (QoL) in patients with lung cancer.

methodsIn this single-blind, 3-arm randomized controlled trial, patients with lung cancer (stages I-IV) were assigned to: (1) usual care, (2) the oncologist's verbal and written exercise recommendation, or (3) the recommendation plus a printed exercise guidebook. Exercise, sedentary behaviors, and QoL were assessed at baseline, 4, and 8 weeks. Descriptive statistics, analysis of variance, and a generalized linear regression model were used to analyze data.

resultsOverall, 91 patients (n = 31 recommendation group, n = 31 recommendation + guidebook group, n = 29 controls) were randomized. At 8 weeks, the recommendation group showed a significant increase in total (+270 min/week, p = 0.03) and light-intensity physical activity (+236 min/week, p = 0.01) versus controls. The recommendation plus guidebook group demonstrated a near-significant increase in total (+251 min/week, p = 0.05) and moderate-intensity physical activity (+145 min/week, p = 0.05). No significant changes were observed for sedentary behaviors. Regarding QoL, at 4 weeks, the recommendation plus guidebook group demonstrated an enhancement in cognitive function and the recommendation group in social function compared to controls. At 8 weeks, the recommendation + guidebook group reported improved constipation compared to the controls.

conclusionsA brief oncologist-delivered recommendation effectively increased the total physical exercise in patients with lung cancer. Combining the oncologist's recommendation with a dedicated guidebook may be more effective in promoting moderate- and vigorous-intensity exercise, although the short follow-up limits conclusions regarding long-term effects.

trial registrationClinicalTrial.gov identifier: NCT05497544.

Indexed as

ExerciseLung NeoplasmsQuality of LifeAgedFemaleHumansMaleMiddle AgedOncologistsSedentary BehaviorSingle-Blind Methodbehavior changeexercise recommendationoncologist‐led interventionphysical exercisequality of life

Identifiers

PMID42036773
PMCPMC13111415

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.