Evidence map›Paper›PMID 42036768›Full record

ArticleMagnetic resonance in medicine2026

5D Flow MRI Reveals Respiration-Driven Changes in Blood Flow Energetics in Congenital Heart Disease.

Thara Nallamothu, Elizabeth K Weiss, Justin Baraboo, Joshua D Robinson, Cynthia K Rigsby, Christopher W Roy, Matthias Stuber, Michael Markl

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thara NallamothuRadiology, Feinberg School of Medicine, Northwestern Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-6466-2711
Elizabeth K WeissRadiology, Feinberg School of Medicine, Northwestern Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-0203-7267
Justin BarabooRadiology, Feinberg School of Medicine, Northwestern Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-7301-0005
Joshua D RobinsonDepartment of Cardiology, Ann & Robert Lurie Children's Hospital, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-2129-5501
Cynthia K RigsbyRadiology, Feinberg School of Medicine, Northwestern Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-1224-2333
Christopher W RoyRadiology, University Hospital Lausanne (CHUV), Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-3111-8840
Matthias StuberRadiology, University Hospital Lausanne (CHUV), Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-9843-2028
Michael MarklRadiology, Feinberg School of Medicine, Northwestern Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-7686-1128

Funding

Graduate Training Program for Magnetic Resonance ImagingT32EB025766 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Michael Markl · 2019 to 2026
$1.6M
Dual-Venc 5D flow for Assessment of Congenital Heart Disease in PediatricsF30HL165805 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WEISS, ELIZABETH · 2023 to 2025
$143k
Arrhythmia-resolved 5D Flow MRI in Atrial Fibrillation and StrokeF31HL165915 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BARABOO, JUSTIN J · 2022 to 2023
$86k
NHLBI NIH HHS F30HL165805NHLBI NIH HHS F31HL165915NHLBI NIH HHS R01HL115828-09NIBIB NIH HHS T32EB025766Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 320030B_201292
6 · The paper itself

Abstract

purposeHemodynamic monitoring is essential for patients with right-sided congenital heart disease (CHD). Respiration may have an increased impact on pulmonary flow in these patients that cannot be assessed by standard tools including 4D flow MRI. This study uses 5D flow MRI to assess respiratory-cycle variations in flow energetics in patients with CHD.

methods5D flow was acquired with four respiratory states in 14 Fontan patients (21 ± 8 years, 8 female), 10 intracardiac shunt patients (19 ± 13 years, 8 female), and 9 controls (26 ± 6 years, 1 female). Blood kinetic energy (KE

results5D flow was acquired with acceleration factor R = 37-93 varying between respiratory states. Fontan and shunt patients demonstrated significant respiratory-driven changes in pulmonary flow energetics compared to controls. Fontan IVC and PA KE

conclusionsThe findings of this study show that CHD flow energetics and efficiency are modulated by respiration. Respiratory-resolved imaging is needed to identify these dynamics and their relationships to overall cardiac function.

Indexed as

Heart Defects, CongenitalMagnetic Resonance ImagingAdolescentAdultBlood Flow VelocityChildFemaleFontan ProcedureHemodynamicsHumansMalePulmonary ArteryRespirationYoung Adult5D flow CMRcongenital heart diseaseFontanrespiratory‐resolved flowshuntsingle ventricle

Identifiers

PMID42036768
PMCPMC13327427

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.