Evidence map›Paper›PMID 42036739›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2026

Differential Ceramide Metabolism in Autogenous and Reactive Obsessions: A Biomarker Perspective in OCD.

Ebru Ozdemir, Filiz Kulacaoglu, Mehmet Atakay, Bekir Salih, Onur Senol

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Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ebru OzdemirDepartment of Psychiatry, University of Health Sciences, Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Türkiye.ORCID https://orcid.org/0009-0003-2352-7534
Filiz KulacaogluDepartment of Psychiatry, University of Health Sciences, Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Türkiye.ORCID https://orcid.org/0000-0001-9800-4971
Mehmet AtakayDepartment of Chemistry, Hacettepe University, Ankara, Türkiye.ORCID https://orcid.org/0000-0002-7102-2974
Bekir SalihDepartment of Chemistry, Hacettepe University, Ankara, Türkiye.ORCID https://orcid.org/0000-0002-8542-6531
Onur SenolDepartment of Analytical Chemistry, Faculty of Pharmacy, Atatürk University, Erzurum, Türkiye.ORCID https://orcid.org/0000-0002-0252-396X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to compare the levels of ceramide pathway metabolites between autogenous and reactive subtypes of patients with obsessive-compulsive disorder (OCD) and healthy controls (HC). Methods: Targeted lipid analyses of ceramide C24:1, hydroxy-ceramide (C24:0 and C18:0), sphingomyelin (SM 16:0), and sphingosine-1-phosphate (S1P) were performed in 52 OCD patients and 27 HC. Patients with OCD group were divided into subgroups based on their primary obsessions: autogenous obsession (AO) and reactive obsession (RO). Sphingolipid species of three groups were compared. Serum samples of ceramide pathway metabolites were analysed by liquid chromatography-mass spectrometry. Results: C18:0 hydroxy-ceramide and S1P levels were significantly higher in patients with OCD than in the HC ( Conclusion: The finding of significantly higher C24:1 ceramide levels in OCD patients with AO may be a novel biomarker that highlights the heterogeneous nature of OCD and the specific neurobiological differences between autogenous and reactive subtypes. This study highlights the role of ceramide pathway metabolites in the pathophysiology of OCD and provides new insights into its underlying mechanisms.

Indexed as

CeramidesObsessive-compulsive disorderSphingolipidsSphingomyelinsSphingosine 1-phosphate

Identifiers

PMID42036739
PMCPMC13122158

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