ArticleGenome biology2026
Highly efficient chromatin conformation capture with post-enrichment in single cells by HiChew.
Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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14 authors.
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Abstract
We present HiChew, a novel chromatin conformation capture method combining efficient sticky-end ligation with post-PCR methylation-based enrichment. HiChew achieves approximately 50% valid pair ratios compared to 8% for unenriched methods, while maintaining high sensitivity. Its single-cell implementation, snHiChew, achieves 45-50% valid pair ratios, and enables 5-10 kb resolution mapping with 70-80% bin coverage. Comparative analyses show strong concordance with conventional Hi-C for chromatin compartments, TADs, and loops. By combining scalability, cost-effectiveness and data quality, HiChew provides a powerful platform for advancing studies of 3D genome architecture analysis.
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