Evidence map›Paper›PMID 42036665›Full record

ArticleAIDS research and therapy2026

Seroprevalence and viremia of hepatitis C virus among HIV-infected patients on ART with unsuppressed HIV viral load in Ethiopia.

Desta Ayana, Gadissa Gutema, Atsbeha Gebreegziabxier, Hana Mekonnen Shewangizaw, Tolewak Sura, Gebremedhin Gebremicael, Dereje Leta, Getachew Tollera, Regasa Diriba, Kassu Desta Tulu and 1 more

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Article in AIDS research and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Desta AyanaInfectious Disease Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. destaayana185@gmail.com.
Gadissa GutemaInfectious Disease Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Atsbeha GebreegziabxierInfectious Disease Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Hana Mekonnen ShewangizawCollege of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.
Tolewak SuraInfectious Disease Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Gebremedhin GebremicaelInfectious Disease Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Dereje LetaInfectious Disease Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Getachew TolleraInfectious Disease Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Regasa DiribaCollege of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.
Kassu Desta TuluCollege of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.
John F DillonDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) share common transmission routes, resulting in a significant burden of co-infection. This study assessed the seroprevalence and viremia of HCV among people living with HIV (PLWH) on ART with unsuppressed viral load in Ethiopia.

methodsA cross-sectional study was conducted between June 2022 and February 2023 among 900 PLWH with unsuppressed viral loads. Plasma samples were screened for HCV antibodies by ELISA, and positives were confirmed for HCV RNA using the Abbott m2000sp/rt PCR system. Data were analyzed using SPSS V 26, applying chi-square tests and logistic regression to assess associations.

resultsAmong 900 participants, 59.3% were females. Overall HCV seroprevalence was 5.4%, with higher rates among females (5.8%) and those aged 40–49 years. Active HCV viremia was confirmed in 14.3% of ELISA-positive cases (0.8% overall). Non-DTG regimens showed higher HCV co-infection (9.7%) than DTG-based regimens (4.4%, p = 0.062). HCV RNA positivity was more frequent in males and participants with medium HIV viral loads.

conclusionA subset of PLWH with unsuppressed viral load showed evidence of HCV exposure and active infection. The result also indicates the exitance of active co-infection HIV/HCV. The data may also reflect spontaneous clearance of HCV or a high rate of past, resolved infections.

Indexed as

CoinfectionHepatitis CHIV InfectionsViremiaAdultCross-Sectional StudiesEthiopiaFemaleHepacivirusHepatitis C AntibodiesHumansMaleMiddle AgedRNA, ViralSeroepidemiologic StudiesViral LoadHepatitis C AntibodiesRNA, ViralEthiopiaHCVHIVPLWHRNASerologicalVirological

Identifiers

PMID42036665
PMCPMC13277263

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