ReviewAdvances in experimental medicine and biology2026
Small Non-coding RNAs and Male Infertility.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Male germ cells carry a complex RNA payload, whose quantity and composition varies during the different stages of spermatogenesis. Small non-coding RNA comprise microRNAs (miRNA), piwi-interacting RNAs (piRNA), tRNA derived small RNAs (tsRNA), endogenous siRNAs, and rRNA-derived small RNAs. MicroRNAs regulate the self-renewal and differentiation of spermatogonial stem cells, as well as their progression through meiosis, while piRNA are thought to play a crucial role at pachytene stage of adult spermatogenesis, since defective piRNA processing has been found in azoospermic men with spermatogenesis arrested mainly at late pachytene spermatocytes, and in preimplantation embryo during epigenetic reprogramming events, when they regulate de novo methylation and repress transposable elements expression. During the transit through the epididymis, sperm acquire a number of miRNA whose composition vary in the caput, corpus, and cauda, which play a fundamental role in embryo development. TsRNA are also acquired in the epididymis, and are involved in sperm maturation, fertilization, and embryonic development. Small noncoding RNA are also responsible for intergenerational and transgenerational epigenetic inheritance of environmental experiences and metabolic disorders and are currently evaluated in the infertile men as diagnostic and prognostic tools, particularly in case of azoospermia due to spermatogenic dysfunction and unexplained infertility in men with normozoospermia.
Indexed as
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42036613What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.