ReviewAdvances in experimental medicine and biology2026
Evaluating Sperm DNA Damage: When and Why It Adds to the Management of the Infertile Man.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most promising markers in the evaluation of male infertility is sperm DNA fragmentation. Studies have shown that the etiology of sperm DNA fragmentation is multifactorial, and includes genetic and developmental abnormalities, ageing, gonadotoxins, hyperthermia, varicocele, medications, and endocrine abnormalities. Clinical studies have demonstrated that sperm DNA damage is associated with poor reproductive outcomes and based on these observation investigators have proposed that tests of sperm DNA fragmentation be used in the evaluation of infertile couples, particularly in those with recurrent pregnancy loss, failed ICSI cycles, and unexplained infertility. An abnormal sperm DNA test in these couples should prompt a thorough evaluation as it may help the clinician uncover the etiology of DNA damage and initiate cause-specific treatment to optimize reproductive outcomes.
Indexed as
Identifiers
42036605What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.