SynthesisAnnals of surgical oncology2026
Does Lymph Node Dissection During Esophagectomy Impact the Long-Term Prognosis for Complete Responders After Neoadjuvant Therapy? A Meta-analysis.
Synthesis in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- ASO Author Reflections: Foundation Models Unlock Lymphovascular Invasion Prediction from Routine Prostate Cancer Histology.Annals of surgical oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundNeoadjuvant therapy followed by esophagectomy has become the standard of care in locally advanced esophageal cancer. However, the adequacy of lymph node dissection (LND) for patients with a pathologic complete response (pCR) during esophagectomy after neoadjuvant therapy remains undetermined. Our meta-analysis aimed to investigate whether adequate LND was associated with survival benefits in complete responders to neoadjuvant therapy.
methodsA systematic online search was conducted to investigate the relationship between the extent of LND and survival in patients with pCR, with overall survival (OS) as the primary endpoint and disease-free survival as the secondary endpoint. Subgroup analyses were performed per LND thresholds, pathology, and geographic regions.
resultsOur study included eight studies involving a total of 2578 patients with pCR. The pooled data demonstrated a significant association between adequacy of LND and improved OS (hazard ratio 0.70; 95% confidence interval 0.58-0.84, p < 0.001). However, no significant survival advantage on disease-free survival was observed (hazard ratio 0.72; 95% confidence interval 0.24-2.20, p = 0.568). Moreover, extensive LND did not bring additional survival benefits to OS when the harvested lymph nodes exceeded 40. Subgroup analyses revealed that adequate LND was significantly associated with superior OS in the Western and adenocarcinoma-predominant populations but not in the Eastern population or in those with squamous cell carcinoma.
conclusionAdequate lymphadenectomy might correlate with better OS in patients with pCR, specifically in those with adenocarcinoma. Our findings suggested that the extent of LND should be tailored to histology and populations, which should be interpreted with caution.
Indexed as
Identifiers
42036602What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.