Evidence map›Paper›PMID 42036551›Full record

ArticleBulletin of experimental biology and medicine2026

The Role of Polymorphism of HLA Class II Genes in Postvaccination Plague Immunity.

K M Korytov, V I Dubrovina, A B Pyatyidesyatnikova, D D Bryukhova, N O Kiseleva, E A Kuzina, S V Balakhonov

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

K M KorytovFederal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk Antiplague Research Institute, Irkutsk, Russia. konstmikhkor@yandex.ru.
V I DubrovinaFederal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk Antiplague Research Institute, Irkutsk, Russia.
A B PyatyidesyatnikovaFederal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk Antiplague Research Institute, Irkutsk, Russia.
D D BryukhovaFederal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk Antiplague Research Institute, Irkutsk, Russia.
N O KiselevaFederal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk Antiplague Research Institute, Irkutsk, Russia.
E A KuzinaFederal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk Antiplague Research Institute, Irkutsk, Russia.
S V BalakhonovFederal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk Antiplague Research Institute, Irkutsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the association of alleles of human leukocyte antigen (HLA) class II genes and the levels of secretion of IL-4 and IFNγ in the blood of individuals vaccinated/revaccinated with a live plague vaccine and living in the Gorno-Altai high-mountain and Tuvinian mountain natural plague foci. Significant differences were identified in the blood content of IL-4 and IFNγ in volunteers with different variants of alleles in the HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci, which indicates a substantial influence of their polymorphism on the immunological reactivity during specific plague prevention. Further research within the framework of immunological monitoring of the population living in plague-endemic territories will allow identifying the features of the influence of polymorphism of HLA class II genes on the formation of post-vaccination anti-plague immunity in humans.

Indexed as

HLA-DQ alpha-ChainsHLA-DQ beta-ChainsHLA-DRB1 ChainsPlaguePlague VaccineAdultAllelesFemaleHumansInterferon-gammaInterleukin-4MalePolymorphism, GeneticVaccinationYersinia pestisHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DQB1 antigenHLA-DQ beta-ChainsHLA-DRB1 ChainsIL4 protein, humanInterferon-gammaInterleukin-4Plague VaccinebloodHLAimmunitylive plague vaccinepolymorphism

Identifiers

PMID42036551

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.