Evidence map›Paper›PMID 42036532›Full record

Observational studyJournal of the Egyptian National Cancer Institute2026

Early cardiotoxicity of radiotherapy in breast cancer patients after chemotherapy: the early warning sign.

Zakka Zayd Zhullatullah Jayadisastra, Muhammad Ivan Aulia Sani, Lucia Kris Dinarti, Hasanah Mumpuni, Susanna Hilda Hutajulu, Wigati Dhamiyati

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the Egyptian National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zakka Zayd Zhullatullah JayadisastraDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.
Muhammad Ivan Aulia SaniDepartment of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.
Lucia Kris DinartiDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.
Hasanah MumpuniDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, Indonesia. hmumpuni@gmail.com.
Susanna Hilda HutajuluHematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.
Wigati DhamiyatiDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsRadiotherapy, like chemotherapy, in breast cancer can cause cardiotoxicity. Research about the combined effect of radiotherapy and chemotherapy on left ventricular diastolic function (LVDD) is limited. Therefore, this study was conducted to see the early effect of radiotherapy in patients after completing chemotherapy.

methodThis research was a prospective analytical observational study with a pre-post design that was conducted from August 2023 to August 2024 in breast cancer patients who had completed their chemotherapy in Sardjito Hospital. The primary endpoint was cardiotoxicity in any level according to European Society of Cardiology (ESC) 2022 cardio-oncology guideline. Cardiotoxicity was diagnosed by considering patients’ history, physical examination, and echocardiography results.

resultTwenty-nine female subjects were enrolled. Seven subjects (24.14%) had cardiotoxicity with one of them was symptomatic. McNemar test showed significant effect of radiotherapy (p = 0.016). Types of chemotherapy were not a confounding factor in this study.

conclusionRadiotherapy may cause mild cardiotoxicity in short term. A routine screening protocol is needed to prevent further complication.

Indexed as

Breast NeoplasmsCardiotoxicityRadiotherapyAdultAgedEchocardiographyFemaleHumansMiddle AgedProspective StudiesCardiotoxicityChemotherapyRadiotherapy

Identifiers

PMID42036532
PMCPMC13262374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.