OsRACK1A Scaffolds MAPK Signaling to Mediate Rice Immunity Against Xanthomonas oryzae pv. oryzicola.

Jiuxiang Wang, Huajun Qin, Yaqi Zhang, Xin Chen, Yongqiang He, Jiliang Tang, Sheng Huang

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Article in Rice (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Jiuxiang WangState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, Guangxi, China.

Huajun QinState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, Guangxi, China.

Yaqi ZhangState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, Guangxi, China.

Xin ChenState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, Guangxi, China.

Yongqiang HeCollege of Agriculture, Guangxi University, Nanning, 530004, Guangxi, China.

Jiliang TangState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, Guangxi, China.

Sheng HuangState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, Guangxi, China. shuang@gxu.edu.cn.

Funding

National Natural Science Foundation of China 32360045 and 31860032

6 · The paper itself

Abstract

Bacterial leaf streak (BLS), caused by Xanthomonas oryzae pv. oryzicola (Xoc), poses a severe threat to rice production. Despite its agricultural impact, the molecular mechanisms underlying rice resistance to Xoc remain largely elusive. In this study, we report that OsRACK1A, a conserved scaffold protein, positively regulates rice resistance to Xoc by modulating the MAPK signaling. Transgenic rice plants overexpressing OsRACK1A exhibit enhanced resistance to Xoc, whereas knockdown lines display heightened susceptibility. This compromised resistance was associated with attenuated activation of mitogen-activated protein kinase (MAPK) cascades and suppressed expression of defense-related genes. Further analysis reveals that OsRACK1A physically interacts with OsMPK3 and OsMPK6 in both the nucleus and the cytoplasm. Additionally, we find that OsRACK1A associates with its homolog, OsRACK1B, suggesting these proteins may form a heteromeric complex to coordinate MAPK activation. Collectively, our findings identify OsRACK1A as a critical positive regulator of rice immunity against Xoc and highlight its potential as a genetic target for breeding disease-resistant crops.

Indexed as

Immune responseMAPK signalingRice resistanceScaffold proteinXanthomonas oryzae pv. oryzicola

Identifiers

PMID42036526

DOI10.1186/s12284-026-00910-y

PMCPMC13260528

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.