Evidence map›Paper›PMID 42036412›Full record

ArticleBone research2026

Loss of PTH 1 receptor signaling in periodontal cells drives cementum dysfunction and molar ankylosis in mice.

Hakan Turkkahraman, Carson Joseph Walton, Tianli Zhu, Nisreen Akel, Silvia Marino, Xue Yuan, Teresita M Bellido

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hakan TurkkahramanDepartment of Orthodontics and Oral Facial Genetics, Indiana University School of Dentistry, Indianapolis, IN, USA.
Carson Joseph WaltonDepartment of Otolaryngology-Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Tianli ZhuDepartment of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, IN, USA.
Nisreen AkelDepartment of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0009-0007-7326-7020
Silvia MarinoDepartment of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Xue YuanDepartment of Otolaryngology-Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. yuanxue@iu.edu.ORCID 0000-0002-8063-9431
Teresita M BellidoDepartment of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. TMBellido@uams.edu.ORCID 0000-0002-8203-7004

Funding

Epithelial stem cell dysfunction in diabetic oral ulcerR03DE033059 · NIDCR · INDIANA UNIVERSITY INDIANAPOLIS · PI YUAN, XUE · 2024 to 2025
$317k
U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01-AR059357U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R03DE033059
6 · The paper itself

Abstract

Parathyroid hormone 1 receptor (PTH1R) signaling is critical for mineral ion homeostasis and skeletal development. Although its role in tooth root formation and eruption is established, its specific functions in adult periodontal tissues and craniofacial integrity remain incompletely defined. Here, we investigated the craniofacial and dentoalveolar phenotypes of mice with conditional deletion of PTH1R in DMP1-Cre-expressing cells. DMP1-Cre;PTH1R

Indexed as

Dental CementumMolarReceptor, Parathyroid Hormone, Type 1Signal TransductionTooth AnkylosisAnimalsIntercellular Signaling Peptides and ProteinsMicePeriodontal LigamentIntercellular Signaling Peptides and ProteinsPTH1R protein, mouseReceptor, Parathyroid Hormone, Type 1

Identifiers

PMID42036412
PMCPMC13111640

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.