ArticleThe Journal of veterinary medical science2026
Echocardiographic evaluation of aortic root size in cats with hypertrophic cardiomyopathy.
Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Enlargement of cardiac structures other than the myocardium including the mitral valve (cats and people) and the aortic root (people) is observed in hypertrophic cardiomyopathy (HCM). Whether aortic root size (ARS) is increased in cats with HCM is unknown. We aimed to determine ARS in cats with HCM with and without obstruction and compare results to healthy control cats and cats with hyperthyroidism (HT4) and systemic hypertension (SH), common differentials of HCM. We hypothesized that cats with HCM have increased ARS. A retrospective observational echocardiographic study in 219 client-owned cats was conducted (161 HCM [97 obstructive, 64 non-obstructive], 37 SH, 21 with a mixed HT4/HCM phenotype). Nine echocardiographic variables characterizing ARS were evaluated (diameter of the aortic valve, sinus of Valsalva, sinotubular junction [STJ], and ascending aorta [AscAo] measured at end-systole and end-diastole and sinus height measured at end-diastole). Multivariable analysis with adjustment for age, sex, treatment, and body weight (BW) and Bonferroni correction were used for group comparisons. There was only a difference between HCM and control for AscAo in diastole (7.82 ± 1.11 mm vs. 8.34 ± 1.43 mm, P<0.0001). The STJ in systole was larger in cats with obstructive compared to non-obstructive HCM (mean difference 0.33 mm; 95% confidence interval 0.04 to 0.62; P=0.021). There was no difference between HCM and SH for ARS, but ARS was larger in cats with SH compared to control. In conclusion, cats with HCM do not have aortic root enlargement beyond differences expected by BW, age, and sex.
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